专利检索 ap:("ONCOGEN LIMITED PARTNERSHIP") AND inv:"LINSLEY, PETER, S." 第 1 页

1.

发明公开
NOVEL PROTEINS WITH ONCOSTATIN M ACTIVITY AND PROCESS FOR THEIR PREPARATION 失效
标题翻译：具有ONCOSTATIN M活性的新蛋白质及其制备方法

公开(公告)号：EP0504291A4

公开(公告)日：1992-10-28

申请号：EP91901400

申请日：1990-12-07

申请人： ONCOGEN LIMITED PARTNERSHIP

发明人： LINSLEY, PETER, S. , KALLESTAD, JEFFREY, C.

IPC分类号： A61K38/00 , A61K38/17 , A61K38/19 , A61P35/00 , C07K20060101 , C07K14/00 , C07K14/435 , C07K14/52 , C12N15/00 , C12N15/01 , C12N15/09 , C12P21/02 , C12P21/06 , C12R1/91 , C07K13/00 , A61K37/00

CPC分类号： C07K14/52 , A61K38/204

摘要： The present invention is directed to biologically mutant forms of the cell growth regulatory factor Oncostatin M. The Oncostatin M mutants of the invention comprise deletion, substitution and insertion mutants and may be prepared using recombinant DNA, in vitro mutagenesis and heterologous expression techniques. Oncostatin M mutants may be useful in eliciting Oncostatin M biological responses and, as such, may find a variety of therapeutic uses including but not limited to the treatment of neoplasias.