-
公开(公告)号：EP3184519A1
公开(公告)日：2017-06-28
申请号：EP15832999.5
申请日：2015-08-17
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , IKURA, Masahiro , HIGASHINO, Masato , KIJIMA, Hideomi , ONO, Shizuka , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D401/12 , A61K31/506 , A61K45/00 , A61P1/04 , A61P11/02 , A61P13/02 , A61P17/04 , A61P17/06 , A61P25/02 , A61P25/06 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D401/14
CPC分类号： C07D401/12 , A61K31/506 , A61K45/00 , A61K45/06 , C07B2200/13 , C07C309/04 , C07C309/29 , C07C309/30 , C07D401/14
摘要： In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and in addition thereto, is excellent in solubility and absorbability against free bases. The compound of the present invention has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and is excellent in solubility and absorbability against free bases, and is therefore useful as a prophylactic and/or therapeutic agent for Trk-related diseases.
摘要翻译： 为了提供Trk相关疾病的预防和/或治疗剂，本发明提供了具有选择性Trk抑制活性并持续抑制NGF血管高渗透性并且不具有药物相互作用的化合物，并且此外， 对游离碱的溶解性和吸收性优异。 本发明的化合物具有选择性Trk抑制活性，持续抑制NGF血管通透性高，不具有药物相互作用，对游离碱具有优异的溶解性和吸收性，因此可用作预防剂和/或治疗剂 为Trk相关的疾病。
-
公开(公告)号：EP4019496A1
公开(公告)日：2022-06-29
申请号：EP20854718.2
申请日：2020-08-19
发明人： OTANI, Shuhei , FUJITO, Takayuki , IMURA, Naoko , KIJIMA, Hideomi , PARENT, Stephan D. , BEVILL, Melanie Janelle , JOHNSON, Courtney S. , HOUSTON, Travis Lee
IPC分类号： C07D205/04
摘要： An object of the present invention is to provide a compound with an improved balance of S1P 5 receptor agonist activity with respect to S1P 1 receptor, and a form suitable for drug substances of pharmaceuticals. Provided is Compound I having high S1P 5 receptor-selective agonist activity on the S1P 1 receptor. In addition, the crystal forms of Compound I, the salts of Compound I, and the crystal forms of salts thereof disclosed in the present invention are provided as drug substances of pharmaceuticals.
-
公开(公告)号：EP3184519B1
公开(公告)日：2019-04-24
申请号：EP15832999.5
申请日：2015-08-17
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , IKURA, Masahiro , HIGASHINO, Masato , KIJIMA, Hideomi , ONO, Shizuka , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D401/12 , A61K31/506 , A61K45/00 , A61P1/04 , A61P11/02 , A61P13/02 , A61P17/04 , A61P17/06 , A61P25/02 , A61P25/06 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D401/14 , C07C309/30
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
