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公开(公告)号：EP3184519B1
公开(公告)日：2019-04-24
申请号：EP15832999.5
申请日：2015-08-17
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , IKURA, Masahiro , HIGASHINO, Masato , KIJIMA, Hideomi , ONO, Shizuka , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D401/12 , A61K31/506 , A61K45/00 , A61P1/04 , A61P11/02 , A61P13/02 , A61P17/04 , A61P17/06 , A61P25/02 , A61P25/06 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D401/14 , C07C309/30
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公开(公告)号：EP3184519A1
公开(公告)日：2017-06-28
申请号：EP15832999.5
申请日：2015-08-17
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , IKURA, Masahiro , HIGASHINO, Masato , KIJIMA, Hideomi , ONO, Shizuka , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D401/12 , A61K31/506 , A61K45/00 , A61P1/04 , A61P11/02 , A61P13/02 , A61P17/04 , A61P17/06 , A61P25/02 , A61P25/06 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D401/14
CPC分类号： C07D401/12 , A61K31/506 , A61K45/00 , A61K45/06 , C07B2200/13 , C07C309/04 , C07C309/29 , C07C309/30 , C07D401/14
摘要： In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and in addition thereto, is excellent in solubility and absorbability against free bases. The compound of the present invention has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and is excellent in solubility and absorbability against free bases, and is therefore useful as a prophylactic and/or therapeutic agent for Trk-related diseases.
摘要翻译： 为了提供Trk相关疾病的预防和/或治疗剂，本发明提供了具有选择性Trk抑制活性并持续抑制NGF血管高渗透性并且不具有药物相互作用的化合物，并且此外， 对游离碱的溶解性和吸收性优异。 本发明的化合物具有选择性Trk抑制活性，持续抑制NGF血管通透性高，不具有药物相互作用，对游离碱具有优异的溶解性和吸收性，因此可用作预防剂和/或治疗剂 为Trk相关的疾病。
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公开(公告)号：EP2960234A1
公开(公告)日：2015-12-30
申请号：EP14753934.0
申请日：2014-02-18
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , HASHIMURA, Kazuya , IKURA, Masahiro , HIGASHINO, Masato , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D213/75 , A61K31/136 , A61K31/444 , A61K31/506 , A61K31/519 , A61K31/663 , A61K45/00 , A61P1/04 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/04 , A61P33/10 , A61P43/00 , C07D239/47 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
CPC分类号： A61K31/506 , A61K31/136 , A61K31/444 , A61K31/519 , A61K31/5377 , A61K31/663 , A61K45/06 , C07D213/75 , C07D239/47 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , Y02A50/414
摘要： The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I):
wherein all symbols represent the same meanings as described in the specification,
a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.摘要翻译： 本发明提供含有具有Trk抑制活性的化合物作为有效成分的药物在预防和/或治疗Trk相关疾病如疼痛，瘙痒，下尿路功能障碍，哮喘，变应性鼻炎，炎性肠病或查加斯 疾病。 由通式（I）表示的化合物：其中所有符号表示与说明书中描述的相同的含义，其盐，其N-氧化物，其溶剂合物或其前药可用作具有Trk- 抑制疾病如疼痛，瘙痒症，下尿路功能障碍，哮喘，过敏性鼻炎，炎性肠病或查加斯病的预防和/或治疗中的活性。
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公开(公告)号：EP2842955A1
公开(公告)日：2015-03-04
申请号：EP13782584.0
申请日：2013-04-25
IPC分类号： C07D417/14 , A61K31/444 , A61K31/506 , A61K31/55 , A61P1/04 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/04 , A61P25/04 , A61P37/08 , A61P43/00
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/513 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D417/12 , Y02A50/414
摘要： An object of the present invention is to provide a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I) :
(wherein all symbols represent the same meanings as described in the specification), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.摘要翻译： 本发明的一个目的是提供含有具有Trk抑制活性的化合物作为活性成分的药物，用于预防和/或治疗诸如疼痛，瘙痒，下尿路功能障碍，哮喘，变应性鼻炎，炎性肠病 或南美锥虫病。 由通式（I）表示的化合物:(其中所有符号表示与说明书中所述的相同的含义），其盐，其N-氧化物，其溶剂合物或其前药可用作药物组分 在预防和/或治疗诸如疼痛，瘙痒症，下尿路功能障碍，哮喘，过敏性鼻炎，炎性肠病或查加斯病等疾病中的Trk抑制活性。
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公开(公告)号：EP3800183A1
公开(公告)日：2021-04-07
申请号：EP20206093.5
申请日：2014-02-18
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , HASHIMURA, Kazuya , IKURA, Masahiro , HIGASHINO, Masato , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D213/75 , A61K31/136 , A61K31/444 , A61K31/506 , A61K31/519 , A61K31/663 , A61K45/00 , A61P1/04 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/04 , A61P33/10 , A61P43/00 , C07D239/47 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04
摘要： The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I):
wherein all symbols represent the same meanings as described in the specification,
a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.-
公开(公告)号：EP3459935A1
公开(公告)日：2019-03-27
申请号：EP18202855.5
申请日：2014-02-18
发明人： TAKEUCHI, Jun , ITADANI, Satoshi , HASHIMURA, Kazuya , IKURA, Masahiro , HIGASHINO, Masato , YASUHIRO, Tetsuya , NAGAURA, Takeshi
IPC分类号： C07D213/75 , A61K31/136 , A61K31/444 , A61K31/506 , A61K31/519 , A61K31/663 , A61K45/00 , A61P1/04 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/04 , A61P33/10 , A61P43/00 , C07D239/47 , C07D401/12 , C07D401/14 , C07D471/04 , C07D487/04 , A61P29/00
摘要： The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I):
wherein all symbols represent the same meanings as described in the specification,
a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.-
公开(公告)号：EP2842955B1
公开(公告)日：2016-10-05
申请号：EP13782584.0
申请日：2013-04-25
IPC分类号： C07D417/14 , A61K31/444 , A61K31/506 , A61K31/55 , A61P1/04 , A61P11/02 , A61P11/06 , A61P13/02 , A61P17/04 , A61P25/04 , A61P37/08 , A61P43/00 , C07D417/12
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/513 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D417/12 , Y02A50/414
摘要： An object of the present invention is to provide a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I) : (wherein all symbols represent the same meanings as described in the specification), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.
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