公开(公告)号：EP3369732A1

公开(公告)日：2018-09-05

申请号：EP18163765.3

申请日：2010-10-27

申请人： ORION CORPORATION

发明人： WOHLFAHRT, Gerd ,  TÖRMÄKANGAS, Olli ,  KARJALAINEN, Arja ,  KNUUTTILA, Pia ,  HOLM, Patrik ,  RASKU, Sirpa ,  VESALAINEN, Anniina ,  SALO, Harri ,  HÖGLUND, Lisa

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D231/12 ,  C07D471/12 ,  C07D487/04 ,  C07D513/04

CPC分类号： C07D513/04 ,  C07D231/12 ,  C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Compounds of formula (I) wherein R 1 to R 16 , A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula ( I ) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

公开(公告)号：EP3885340A1

公开(公告)日：2021-09-29

申请号：EP21169615.8

申请日：2010-10-27

申请人： ORION CORPORATION

发明人： WOHLFAHRT, Gerd ,  TÖRMÄKANGAS, Olli ,  KARJALAINEN, Arja ,  KNUUTTILA, Pia ,  HOLM, Patrik ,  RASKU, Sirpa ,  VESALAINEN, Anniina ,  SALO, Harri ,  HÖGLUND, Lisa

IPC分类号： C07D231/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  A61P35/00 ,  A61K31/42 ,  A61K31/438 ,  A61K31/497 ,  A61K31/4523 ,  A61K31/416 ,  A61K31/44

摘要： Compounds of formula ( I ) wherein R 1 to R 16 , A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula ( I ) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.