公开(公告)号：EP1797054A2

公开(公告)日：2007-06-20

申请号：EP05778352.4

申请日：2005-08-01

申请人： OSI Pharmaceuticals, Inc.

发明人： AHMED, Saleh ,  BARBA, Oscar ,  BLOXHAM, Jason ,  DAWSON, Graham ,  GATTRELL, William ,  KITCHIN, John ,  PEGG, Neil Anthony ,  SABA, Imaad ,  SADIQ, Shazia ,  SAMBROOK SMITH, Colin Peter ,  SMYTH, Don ,  STEINIG, Arno G. ,  WILKES, Robin ,  FOREMAN, Kenneth ,  WENG, Qinghua Felix ,  STOLZ, Kathryn ,  TAVARES, Paula ,  PANICKER, Bijoy ,  LI, An-Hu ,  DONG, Hanqing ,  MA, Lifu ,  COX, Matthew

IPC分类号： C07D295/185 ,  C07D295/02 ,  C07D223/04 ,  C07D487/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/5513 ,  A61K31/55

CPC分类号： C07D471/02 ,  C07D487/02 ,  C07D487/04

摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

摘要翻译： 由式（I）表示的化合物或其立体异构体或药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mek1，PDK中至少两种的抑制剂 -1，GSK3β，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶用于治疗和/或预防各种疾病和病症，例如 癌症。