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1.发明授权
公开(公告)号：EP1355639B1
公开(公告)日：2006-04-12
申请号：EP02716434.2
申请日：2002-01-29
IPC分类号： A61K31/00 , A61K31/496 , A61K45/06 , A61P25/24 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/06 , A61P25/30 , A61P15/00 , A61P3/04 , A61P1/08 , A61P25/00 , A61P25/32
CPC分类号： A61K31/00 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The present invention relates to use of a compound for the production of a medicament for treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, which the medicament comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1), wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond; and a pharmaceutically acceptable salt or solvate thereof.
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2.发明公开PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS 有权PIPERAZINSUBSTITUIERTE苯并精神疾病的治疗
公开(公告)号：EP1869025A1
公开(公告)日：2007-12-26
申请号：EP06732069.7
申请日：2006-04-12
发明人： YAMASHITA, Hiroshi, , MATSUBARA, Jun , OSHIMA, Kunio , KURODA, Hideaki , ITO, Nobuaki , MIYAMURA, Shin , SHIMIZU, Satoshi , TANAKA, Tatsuyoshi , OSHIRO, Yasuo , SHIMADA, Jun , MAEDA, Kenji , TADORI, Yoshihiro , AMADA, Naoki , AKAZAWA, Hitomi , YAMASHITA, Junko , MORI, Atsushi , UWAHODO, Yasufumi , MASUMOTO, Takumi , KIKUCHI, Tetsuro , HASHIMOTO, Kazuya , TAKAHASHI, Haruka
IPC分类号： C07D409/12
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
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3.发明公开
公开(公告)号：EP1355639A2
公开(公告)日：2003-10-29
申请号：EP02716434.2
申请日：2002-01-29
IPC分类号： A61K31/00 , A61K31/496 , A61K45/06 , A61P25/24 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/06 , A61P25/30 , A61P15/00 , A61P3/04 , A61P1/08
CPC分类号： A61K31/00 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The present invention relates to use of a compound for the production of a medicament for treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, which the medicament comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1), wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond; and a pharmaceutically acceptable salt or solvate thereof.
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4.发明公开
公开(公告)号：EP0749311A1
公开(公告)日：1996-12-27
申请号：EP95940447.0
申请日：1995-12-15
发明人： KIKUCHI, Tetsuro , TOTTORI, Katsura , UWAHODO, Yasufumi , TANAKA, Hideo , ICHIKAWA, Hiroyuki , ONO, Yukihisa 41-18, Aza Kawakubo , NAKAI, Satoru 67-4, Aza Minami-kawamukou
IPC分类号： A61K31
CPC分类号： A61K31/4965
摘要： The present invention provides a pharmaceutical composition for regulating apoptosis containing at least one active ingredient selected from the group consisting of 2,3-dihydro-1H-indene derivatives represented by general formula (I), (wherein R?1, R2, R3 and R4¿ are each the same or different and are lower alkyl groups; R5 is a lower alkoxy group; and A is a lower alkylene group) and salts thereof. The present invention also provides methods for treating and preventing various diseases by regulating apoptosis by use of said pharmaceutical composition.
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