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1.发明授权
公开(公告)号：EP2544682B1
公开(公告)日：2016-02-10
申请号：EP11709175.1
申请日：2011-03-11
发明人： PAROLARO, Daniela , MASSI, Paola , IZZO, Angelo Antonio , BORELLI, Francesca , AVIELLO, Gabriella , DI MARZO, Vincenzo , DE PETROCELLIS, Luciano , MORIELLO, Aniello Schiano , LIGRESTI, Alessia , ROSS, Ruth Alexandra , FORD, Lesley Ann , ANAVI-GOFFER, Sharon , GUZMAN, Manuel , VELASCO, Guillermo , LORENTE, Mar , TORRES, Sofia , KIKUCHI, Tetsuro , GUY, Geoffrey , STOTT, Colin , WRIGHT, Stephen , SUTTON, Alan , POTTER, David , DE MEIJER, Etienne
IPC分类号： A61K45/06 , A61K31/05 , A61K31/192 , A61K31/337 , A61K31/4188 , A61K31/352 , A61K36/185
CPC分类号： A61K36/185 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/192 , A61K31/337 , A61K31/352 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.
摘要翻译： 本发明涉及在治疗癌症中以分离形式或以植物药物（BDS）的形式使用植物大麻素。 优选地，待治疗的癌症是前列腺癌，乳腺癌或结肠癌。
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公开(公告)号：EP2709604A1
公开(公告)日：2014-03-26
申请号：EP12722495.4
申请日：2012-05-18
IPC分类号： A61K31/05 , A61K31/185 , A61K31/352 , A61P25/02
CPC分类号： A61K31/352 , A61K31/05
摘要： The present invention relates to cannabinoids for use in the treatment of neuropathic pain. Preferably the cannabinoids are one or more phytocannabinoids of: cannabigerol (CBG), cannabichromene (CBC), cannabidivarin (CBDV) or tetrahydrocannabivarin (THCV). More preferably the phytocannabinoids are isolated and/or purified from cannabis plant extracts.
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3.发明公开PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS 有权PIPERAZINSUBSTITUIERTE苯并精神疾病的治疗
公开(公告)号：EP1869025A1
公开(公告)日：2007-12-26
申请号：EP06732069.7
申请日：2006-04-12
发明人： YAMASHITA, Hiroshi, , MATSUBARA, Jun , OSHIMA, Kunio , KURODA, Hideaki , ITO, Nobuaki , MIYAMURA, Shin , SHIMIZU, Satoshi , TANAKA, Tatsuyoshi , OSHIRO, Yasuo , SHIMADA, Jun , MAEDA, Kenji , TADORI, Yoshihiro , AMADA, Naoki , AKAZAWA, Hitomi , YAMASHITA, Junko , MORI, Atsushi , UWAHODO, Yasufumi , MASUMOTO, Takumi , KIKUCHI, Tetsuro , HASHIMOTO, Kazuya , TAKAHASHI, Haruka
IPC分类号： C07D409/12
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
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4.发明公开CARBOSTYRIL DERIVATIVES AND MOOD STABILIZERS FOR TREATING MOOD DISORDERS 有权喹诺酮情绪障碍的BEHANLDUNG衍生物和情绪稳定剂
公开(公告)号：EP1626721A2
公开(公告)日：2006-02-22
申请号：EP04785621.6
申请日：2004-05-19
IPC分类号： A61K31/47 , A61K31/19 , A61K31/519
CPC分类号： A61K31/496 , A61K31/19 , A61K31/195 , A61K31/357 , A61K31/4015 , A61K31/423 , A61K31/425 , A61K31/4704 , A61K31/497 , A61K31/53 , A61K31/55 , A61K31/5513 , A61K31/7008 , A61K33/00 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-serotonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamazapine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.
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公开(公告)号：EP3718603A1
公开(公告)日：2020-10-07
申请号：EP20175934.7
申请日：2010-06-29
发明人： WHALLEY, Benjamin , STEPHENS, Gary , WILLIAMS, Claire , GUY, Geoffrey , WRIGHT, Stephen , KIKUCHI, Tetsuro
IPC分类号： A61P25/08 , A61K31/352
摘要： This invention relates to the use of one or more cannabinoids in the treatment of epilepsy and more particularly to the use of one or a combination of cannabinoids in the treatment of generalized or partial seizure. In one embodiment it relates to the use of the cannabinoid THCV, as a pure or isolated compound, or as a plant extract in which significant amounts of any THC naturally present has been selectively removed. In another embodiment the phytocannabinoid is CBD.
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6.发明授权COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER 有权包含非那吡唑或其盐和第二种药物的组合用于治疗中枢神经系统疾病
公开(公告)号：EP2694043B1
公开(公告)日：2017-11-01
申请号：EP12719460.3
申请日：2012-04-04
IPC分类号： A61K31/00 , A61K31/496 , A61P25/00
CPC分类号： A61K31/496 , A61K9/20 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/4525 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The present invention provides a medicament having a wider treatment spectrum, causing a fewer side effects and superior in tolerability and safety, as compared to known typical antipsychotic agents and atypical antipsychotic agents. The present invention related to a medicament containing (I) a compound which is 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof, and (II) at least one drug selected from the group consisting of a mood stabilizer, a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a serotonin and norepinephrine reuptake inhibitor, a noradrenergic and specific serotonergic antidepressant, an antianxiety drug, a tricyclic antidepressant, a tetracyclic antidepressant, an antipsychotic drug and an anti-ADHD drug, in combination.
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7.发明公开CARBOSTYRIL DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS FOR TREATMENT OF MOOD DISORDERS 有权选择性血清素抑制剂录制的喹诺酮衍生物，MIND疾病治疗
公开(公告)号：EP1575590A1
公开(公告)日：2005-09-21
申请号：EP03786308.1
申请日：2003-12-25
IPC分类号： A61K31/496 , A61K31/381 , A61K31/343 , A61K31/15 , A61K31/4525 , A61K31/135 , A61P25/24
CPC分类号： A61K31/496 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/4525 , A61K2300/00
摘要： The pharmaceutical composition of the present invention comprises (1) a carbostyril derivative and (2) a serotonin reuptake inhibitor in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof, which is a dopamine-serotonin system stabilizer. The serotonin reuptake inhibitor may be fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine, sertraline or escitalopram. The pharmaceutical composition of the present invention is useful for treating patients with mood disorders, particularly depression or major depressive disorder.
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8.发明公开USE OF CANNABIDIOL IN COMBINATION WITH ARIPIPRAZOLE 审中-公开VERWENDUNG VON CANNABIDIOL在KOMBINATION MIT ARIPRIPRAZOL
公开(公告)号：EP3095452A1
公开(公告)日：2016-11-23
申请号：EP16167562.4
申请日：2008-12-17
发明人： KIKUCHI, Tetsuro , MAEDA, Kenji , GUY, Geoffrey , ROBSON, Philip , STOTT, Colin
IPC分类号： A61K36/185 , A61K31/352 , A61K31/35 , A61K31/05 , A61K45/06 , A61P25/18 , A61P25/22
CPC分类号： A61K45/06 , A61K31/05 , A61K31/35 , A61K31/352 , A61K36/185 , A61K2300/00
摘要： The present invention relates to the use of one or more cannabinoids in combination with one or more anti-psychotic medicaments for use in the prevention or treatment of psychosis and psychotic disorders. Preferably the one or more cannabinoids are taken from the group: cannabidiol (CBD); cannabidiolic acid (CBDA); tetrahydrocannbidivarin (THCV); tetrahydrocannbidivarinin acid (THCVA); cannabichromene (CBC); cannabichromenic acid (CBCA); cannabigerol (CBG) and cannabigerolic acid (CBGA). Preferably the anti-psychotic medication is an atypical anti-psychotic medication.
摘要翻译： 本发明涉及一种或多种大麻素与一种或多种抗精神病药物组合用于预防或治疗精神病和精神病性障碍的用途。 优选地，一种或多种大麻素取自组：大麻二醇（CBD）; 大辛二酸（CBDA）; 四氢甘比多巴（THCV）; 四氢胆碱尿苷酸（THCVA）; 大麻色素（CBC）; 大麻黄酸（CBCA）; 大麻素（CBG）和大麻酚酸（CBGA）。 优选地，抗精神病药物是非典型的抗精神病药物。
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公开(公告)号：EP2544682A1
公开(公告)日：2013-01-16
申请号：EP11709175.1
申请日：2011-03-11
发明人： PAROLARO, Daniela , MASSI, Paola , IZZO, Angelo Antonio , BORELLI, Francesca , AVIELLO, Gabriella , DI MARZO, Vincenzo , DE PETROCELLIS, Luciano , MORIELLO, Aniello Schiano , LIGRESTI, Alessia , ROSS, Ruth Alexandra , FORD, Lesley Ann , ANAVI-GOFFER, Sharon , GUZMAN, Manuel , VELASCO, Guillermo , LORENTE, Mar , TORRES, Sofia , KIKUCHI, Tetsuro , GUY, Geoffrey , STOTT, Colin , WRIGHT, Stephen , SUTTON, Alan , POTTER, David , DE MEIJER, Etienne
IPC分类号： A61K31/352 , A61K36/185 , A61P35/00
CPC分类号： A61K36/185 , A61K31/01 , A61K31/015 , A61K31/05 , A61K31/192 , A61K31/337 , A61K31/352 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.
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10.发明公开USE OF ONE OR A COMBINATION OF PHYTO-CANNABINOIDS IN THE TREATMENT OF EPILEPSY 有权使用一个PHYTOCANNABINOIDS或phytocannabinoids的组合用于治疗癫痫
公开(公告)号：EP2448637A1
公开(公告)日：2012-05-09
申请号：EP10734541.5
申请日：2010-06-29
发明人： WHALLEY, Ben , STEPHENS, Gary , WILLIAMS, Claire , GUY, Geoffrey , WRIGHT, Stephen , KIKUCHI, Tetsuro
IPC分类号： A61P25/08 , A61K31/352
CPC分类号： A61K31/05 , A61K31/352
摘要： This invention relates to the use of one or more cannabinoids in the treatment of epilepsy and more particularly to the use of one or a combination of cannabinoids in the treatment of generalized or partial seizure. In one embodiment it relates to the use of the cannabinoid THCV, as a pure or isolated compound, or as a plant extract in which significant amounts of any THC naturally present has been selectively removed. In another embodiment the phytocannabinoid is CBD.
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