公开(公告)号：EP2958994A4

公开(公告)日：2016-11-23

申请号：EP14754562

申请日：2014-02-20

申请人： CHILDREN S HOSPITAL OF EASTERN ONTARIO RES INST INC ,  OTTAWA HOSPITAL RES INST ,  UNIV MCMASTER

发明人： STOJDL DAVID F ,  BELL JOHN CAMERON ,  LICHTY BRIAN ,  POL JONATHAN

IPC分类号： C12N7/01 ,  A61K35/76 ,  A61K39/00 ,  A61P35/00 ,  A61P37/04 ,  C07K14/145 ,  C07K14/47 ,  C07K19/00 ,  C12N15/113 ,  C12N15/12 ,  C12N15/47 ,  C12N15/62 ,  C12N15/86

CPC分类号： A61K39/0005 ,  A61K35/766 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/585 ,  C07K2319/00 ,  C07K2319/50 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/16234 ,  C12N2710/20034 ,  C12N2740/15043 ,  C12N2760/20223 ,  C12N2760/20232 ,  C12N2760/20242 ,  C12N2760/20243 ,  A61K2300/00

摘要： There is described a kit for use in inducing an immune response in a mammal, the kit includes: a first virus that expresses MAGEA3, Human Papilloma Virus E6/E7 fusion protein, human Six-Transmembrane Epithelial Antigen of the Prostate protein, or Cancer Testis Antigen 1, or a variant thereof as an antigenic protein and that is formulated to generate an immunity to the protein or variant thereof in the mammal. The kit also includes a Maraba MG1 virus encoding the same antigen, or a variant of the same antigen. The Maraba MG1 virus is formulated to induce the immune response in the mammal. The first virus is immunologically distinct from the Maraba MG1 virus.

公开(公告)号：EP2510088A4

公开(公告)日：2013-09-18

申请号：EP10835567

申请日：2010-12-10

申请人： OTTAWA HOSPITAL RES INST ,  CHILDREN S HOSPITAL OF EASTERN ONTARIO RES INST INC

发明人： BELL JOHN C ,  STOJDL DAVID F

IPC分类号： C12N7/01 ,  A61K35/76 ,  A61P35/00 ,  C07K14/145 ,  C12N7/04 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K35/766 ,  A61K35/768 ,  A61K45/06 ,  C12N2760/20021 ,  C12N2760/20032 ,  C12N2760/20062 ,  C12N2760/20071 ,  A61K2300/00

摘要： Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.

公开(公告)号：EP2718427A4

公开(公告)日：2014-12-24

申请号：EP12796050

申请日：2012-06-07

申请人： CHILDREN S HOSPITAL OF EASTERN ONTARIO RES INST INC

发明人： STOJDL DAVID F

IPC分类号： C12N7/01 ,  A61K35/76 ,  A61K39/12 ,  A61P35/00 ,  A61P37/04 ,  C07K14/145 ,  C12N15/47 ,  C12N15/86

CPC分类号： A61K39/205 ,  A61K35/766 ,  A61K38/00 ,  A61K2039/572 ,  A61K2039/585 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/00032 ,  C12N2760/20021 ,  C12N2760/20022 ,  C12N2760/20023 ,  C12N2760/20032 ,  C12N2760/20043

摘要： The present disclosure concerns an oncolytic virus for the treatment of cancer, such as in brain cancer, for example glioblastoma. The oncolytic virus may exhibit reduced levels of neurotoxicity. The oncolytic virus may be an isolated viral particle capable of producing a cDNA polynucleotide that includes a sequence according to SEQ ID NO: 1 when the virus is in a host cell. The oncolytic virus may be an isolated viral particle that includes an RNA polynucleotide that includes a sequence according to SEQ ID NO: 2. The oncolytic virus may be an isolated viral particle having a genome that includes open reading frames that encode: proteins having sequences comprising SEQ ID NOs: 3, 4, 5, 6 and 7; or variants thereof.

摘要翻译： 本公开涉及用于治疗癌症的溶瘤病毒，例如在脑癌中，例如成胶质细胞瘤。 溶瘤病毒可能表现出降低的神经毒性水平。 当病毒在宿主细胞中时，溶瘤病毒可以是能够产生包含根据SEQ ID NO：1的序列的cDNA多核苷酸的分离的病毒颗粒。 溶瘤病毒可以是分离的病毒颗粒，其包括包含根据SEQ ID NO：2的序列的RNA多核苷酸。溶瘤病毒可以是分离的病毒颗粒，其具有包含开放阅读框的基因组，所述基因组编码：具有包含 SEQ ID NO：3,4,5,6和7; 或其变体。