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公开(公告)号：EP3189136A1
公开(公告)日：2017-07-12
申请号：EP15838658.1
申请日：2015-09-08
发明人： WIMMER, Eckard , MUELLER, Steffen , FUTCHER, Bruce , SHEN, Sam , STAUFT, Charles , WARD, Charles
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2760/12234 , C12N2760/12262 , C12N2760/20062 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , C12N2800/22 , Y02A50/386
摘要： This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.
摘要翻译： 本发明提供了包含经修饰的病毒基因组的减毒病毒，所述病毒基因组经工程改造而含有多个核苷酸置换，所述多个核苷酸置换降低病毒蛋白质编码序列相对于第一个宿主的密码子对偏倚，而相对于第二个宿主的密码子对偏倚实质上没有降低。 在另一个实施方案中，本发明提供了包含经修饰的病毒基因组的减毒病毒，所述病毒基因组经改造以含有多个核苷酸取代，所述多个核苷酸取代相对于第一宿主和第二宿主降低编码病毒蛋白的序列的密码子对偏倚。 减毒病毒可用于疫苗组合物中以在受试者中诱导保护性免疫应答。 本发明还提供了合成减毒病毒的方法。 此外，本发明进一步提供了用于预防对象患病毒相关疾病的方法，包括给予对象预防有效剂量的包含减毒病毒的疫苗组合物。
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公开(公告)号：EP2510088B1
公开(公告)日：2016-10-05
申请号：EP10835567.8
申请日：2010-12-10
申请人： Ottawa Hospital Research Institute , Children's Hospital of Eastern Ontario Research Institute Inc.
发明人： BELL, John, C. , STOJDL, David, F.
CPC分类号： C12N7/00 , A61K35/766 , A61K35/768 , A61K45/06 , C12N2760/20021 , C12N2760/20032 , C12N2760/20062 , C12N2760/20071 , A61K2300/00
摘要： Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.
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公开(公告)号：EP3189136A4
公开(公告)日：2018-04-04
申请号：EP15838658
申请日：2015-09-08
发明人： WIMMER ECKARD , MUELLER STEFFEN , FUTCHER BRUCE , SHEN SAM , STAUFT CHARLES , WARD CHARLES
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N2760/12234 , C12N2760/12262 , C12N2760/20062 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , C12N2800/22
摘要： This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.
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公开(公告)号：EP2510088A4
公开(公告)日：2013-09-18
申请号：EP10835567
申请日：2010-12-10
发明人： BELL JOHN C , STOJDL DAVID F
CPC分类号： C12N7/00 , A61K35/766 , A61K35/768 , A61K45/06 , C12N2760/20021 , C12N2760/20032 , C12N2760/20062 , C12N2760/20071 , A61K2300/00
摘要： Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.
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公开(公告)号：EP2510088A2
公开(公告)日：2012-10-17
申请号：EP10835567.8
申请日：2010-12-10
申请人： Ottawa Hospital Research Institute , Children's Hospital of Eastern Ontario Research Institute Inc.
发明人： BELL, John, C. , STOJDL, David, F.
CPC分类号： C12N7/00 , A61K35/766 , A61K35/768 , A61K45/06 , C12N2760/20021 , C12N2760/20032 , C12N2760/20062 , C12N2760/20071 , A61K2300/00
摘要： Embodiments of the invention include compositions and methods related to Maraba virus and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.
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