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公开(公告)号：EP2861228A1
公开(公告)日：2015-04-22
申请号：EP13804724.6
申请日：2013-06-10
IPC分类号： A61K31/26 , A61K31/095 , A61K9/20 , A61K9/48 , A61P29/00
CPC分类号： A61K9/0014 , A61K9/0053 , A61K9/06 , A61K31/095 , A61K47/24 , A61K47/32
摘要： The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ω-(methylthio)alkylnitriles such as 3- (methylthio)propionitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
摘要翻译： 本发明涉及包含药学上可接受的载体和3-（甲硫基）丙腈或其药学上可接受的盐的药物组合物。 本发明涉及通过将ω-（甲硫基）烷基腈例如3-（甲硫基）丙腈或其药学上可接受的盐或溶剂化物给予有需要的受试者来治疗炎症，炎症相关病症或疼痛的方法 它们。
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公开(公告)号：EP2858634A1
公开(公告)日：2015-04-15
申请号：EP13804151.2
申请日：2013-06-06
CPC分类号： A61K31/16 , A61K9/0014 , A61K9/0053 , A61K9/06 , A61K31/145 , A61K47/08 , A61K47/14 , A61K47/18 , A61K47/32
摘要： The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
摘要翻译： 本发明涉及药物组合物，其包含药学上可接受的载体和ω-（甲基磺酰基）烷基胺或ω-（甲基磺酰基）烷基酰胺。 本发明还涉及通过将ω-（甲基磺酰基）烷基胺或ω-（甲基磺酰基）烷基酰胺或其药学上可接受的盐或溶剂合物给予有需要的受试者来治疗炎症，炎症相关病症或疼痛的方法 它们。
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公开(公告)号：EP2854786A1
公开(公告)日：2015-04-08
申请号：EP13800483.3
申请日：2013-06-04
IPC分类号： A61K31/10 , A61K31/095 , A61P29/00 , A61P25/00
CPC分类号： A61K31/275
摘要： The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
摘要翻译： 本发明涉及包含药学上可接受的载体和甲磺酰基烷基腈化合物或其药学上可接受的盐或溶剂化物的药物组合物。 本发明还涉及通过将甲磺酰基烷基锡化合物或其药学上可接受的盐或溶剂合物给予有需要的受试者来治疗炎症，炎症相关病症或疼痛的方法。
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公开(公告)号：EP2854785A1
公开(公告)日：2015-04-08
申请号：EP13800363.7
申请日：2013-06-04
CPC分类号： A61K31/277 , A61K9/0014 , A61K47/08 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34
摘要： The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a ω-(arylsulfonyl)alkylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering an ω-(arylsulfonyl)alkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
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公开(公告)号：EP2819995A1
公开(公告)日：2015-01-07
申请号：EP13755546.2
申请日：2013-02-26
IPC分类号： C07C315/02 , C07C317/04 , C07C253/32 , C07C255/03
CPC分类号： C07C315/02 , C07B2200/13 , C07C315/00 , C07C315/06 , C07C317/28 , C07C317/44
摘要： The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3- methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9 ± 0.1, 19.2± 0.1, 20.0± 0.1, 22.5± 0.1, 23.2± 0.1, 25.7± 0.1, 28.1± 0.1, 29.9± 0.1, and 30.6± 0.1 degrees 20, and wherein the most intense peak is the peak at 13.9 ± 0.1 degrees 20.
摘要翻译： 本发明涉及制备3-甲基磺酰基丙腈的方法。 这些方法提供了良好的收率和最终产品的高纯度，并提供了可控的反应。 本发明还涉及具有在13.9±0.1,19.2±0.1,20.0±0.1,22.5±0.1,23.2±0.1,25.7±0.1,28.1±0.1,29.9±2的X射线衍射峰的3-甲基磺酰基丙腈的结晶形式 0.1和30.6±0.1度20，并且其中最强的峰是在13.9±0.1度20处的峰。
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