公开(公告)号：EP3473705A1

公开(公告)日：2019-04-24

申请号：EP17815338.3

申请日：2017-06-19

申请人： Organ Technologies, Inc. ,  Riken

发明人： TSUJI, Takashi ,  TOYOSHIMA, Koh-ei ,  OGAWA, Miho

IPC分类号： C12N5/071 ,  A61L27/36 ,  A61L27/60 ,  C12N5/0775

摘要： The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps:
(A) : a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and
(B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A);
wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.

公开(公告)号：EP3501448A1

公开(公告)日：2019-06-26

申请号：EP17841484.3

申请日：2017-08-14

申请人： Organ Technologies, Inc. ,  RIKEN ,  National University Corporation Okayama University

发明人： TSUJI, Takashi ,  OSHIMA, Masamitsu ,  KUBOKI, Takuo ,  ANDO, Yoshiki ,  OGAWA, Miho

IPC分类号： A61C8/00

摘要： The present invention provides a dental implant device comprising a dental implant body and an implant fixture. Said implant fixture is characterized in that it comprises a portion to be fixed to said implant body and a portion to be fixed to a tooth adjacent to the transplantation site of said implant body in a subject, and is configured so that mechanical stimulation from the tooth adjacent to said transplantation site is transmissible to said implant body, and said implant device is characterized in that it is placed into the oral cavity of said subject so that said implant body is inserted at said transplantation site while said implant fixture is fixed to said implant body and the tooth adjacent to said transplantation site.

公开(公告)号：EP3865570A1

公开(公告)日：2021-08-18

申请号：EP19867367.5

申请日：2019-09-19

申请人： Organ Technologies, Inc. ,  Kyocera Corporation ,  RIKEN

发明人： TSUJI, Takashi ,  ASAKAWA, Kyosuke ,  TAKEO, Makoto ,  TOYOSHIMA, Koh-ei ,  OGAWA, Miho ,  MORI, Yutaka ,  KISHIMOTO, Kyosuke

IPC分类号： C12N5/071 ,  A61K35/36 ,  A61L27/36 ,  A61L27/38 ,  A61L27/60 ,  A61P17/14

摘要： [PROBLEM] To provide means for efficient growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs.
[SOLUTION MEANS] Provided are a culture medium for growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs, the culture medium comprising basal medium and at least (1) through (3) below; and a method for growing the epithelial cells using the culture medium: (1) at least one species of BMP inhibitor; (2) at least one species of fibroblast growth factor; and (3) at least one species of sonic hedgehog (SHH) and/or SHH agonist.