公开(公告)号：EP3523315A1

公开(公告)日：2019-08-14

申请号：EP17859300.0

申请日：2017-10-06

申请人： Oric Pharmaceuticals, Inc.

发明人： SUN, Daqing ,  MCGEE, Lawrence R. ,  DU, Xiaohui ,  ZHU, Liusheng ,  YAN, Xuelei ,  REW, Yosup ,  EKSTEROWICZ, John ,  MEDINA, Julio C. ,  FANTIN, Valeria R. ,  ZHOU, Haiying ,  BALBAS, Minna Delarae

IPC分类号： C07J17/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00

公开(公告)号：EP3851444A1

公开(公告)日：2021-07-21

申请号：EP21158497.4

申请日：2017-10-06

申请人： Oric Pharmaceuticals, Inc.

发明人： SUN, Daqing ,  MCGEE, Lawrence R. ,  DU, Xiaohui ,  ZHU, Liusheng ,  YAN, Xuelei ,  REW, Yosup ,  EKSTEROWICZ, John ,  MEDINA, Julio C. ,  FANTIN, Valeria R. ,  ZHOU, Haiying ,  BALBAS, Minna Delarae

IPC分类号： C07J17/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  A61K31/567 ,  A61K31/569 ,  A61K31/58 ,  A61P5/46 ,  C07J21/00 ,  C07J31/00 ,  C07J71/00

摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.

公开(公告)号：EP3394079A1

公开(公告)日：2018-10-31

申请号：EP16880126.4

申请日：2016-12-22

申请人： Oric Pharmaceuticals, Inc.

发明人： SUN, Daqing ,  MCGEE, Lawrence R. ,  DU, Xiaohui ,  ZHU, Liusheng ,  YAN, Xuelei ,  REW, Yosup ,  EKSTEROWICZ, John ,  MEDINA, Julio C. ,  ZHOU, Haiying ,  BALBAS, Minna Delarae ,  FANTIN, Valeria R.

IPC分类号： C07J1/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  A61K31/565 ,  A61K31/567 ,  A61K31/58

CPC分类号： C07J43/003 ,  A61K31/575 ,  A61K31/58 ,  A61K45/06 ,  C07B2200/05 ,  C07J1/0011 ,  C07J1/0096 ,  C07J17/00 ,  C07J21/006 ,  C07J21/008 ,  C07J41/0083 ,  C07J71/001

摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

公开(公告)号：EP3394078A1

公开(公告)日：2018-10-31

申请号：EP16880121.5

申请日：2016-12-22

申请人： Oric Pharmaceuticals, Inc.

发明人： SUN, Daqing ,  MCGEE, Lawrence R. ,  DU, Xiaohui ,  ZHU, Liusheng ,  YAN, Xuelei ,  REW, Yosup ,  EKSTEROWICZ, John ,  MEDINA, Julio C. ,  ZHOU, Haiying ,  BALBAS, Minna Delarae ,  FANTIN, Valeria R.

IPC分类号： C07J1/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  A61K31/565 ,  A61K31/567 ,  A61K31/58

CPC分类号： C07J51/00 ,  A61K31/277 ,  A61K31/473 ,  A61K31/567 ,  A61K31/57 ,  A61K31/58 ,  A61K45/06 ,  C07B2200/05 ,  C07J1/0096 ,  C07J17/00 ,  C07J21/006 ,  C07J31/006 ,  C07J41/0083 ,  C07J41/0088 ,  C07J41/0094 ,  C07J43/003 ,  C07J71/001 ,  A61K2300/00

摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.