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公开(公告)号：EP4051688A1
公开(公告)日：2022-09-07
申请号：EP20883288.1
申请日：2020-10-29
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公开(公告)号：EP3787635A1
公开(公告)日：2021-03-10
申请号：EP19796584.1
申请日：2019-04-30
发明人： DU, Xiaohui , EKSTEROWICZ, John , FANTIN, Valeria, R. , SUN, Daqing , YE, Qiuping , MOORE, Jared , ZAVOROTINSKAYA, Tatiana , BLANK, Brian, R. , REW, Yosup , WU, Kejia , ZHU, Liusheng , PHAM, Johnny , KAWAI, Hiroyuki
IPC分类号： A61K31/662 , C07F9/6561 , A61K45/06 , A61K31/12 , A61K31/10 , A61P25/28
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公开(公告)号：EP3523315A1
公开(公告)日：2019-08-14
申请号：EP17859300.0
申请日：2017-10-06
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公开(公告)号：EP3999517A1
公开(公告)日：2022-05-25
申请号：EP20841341.9
申请日：2020-07-15
发明人： DU, Xiaohui , EKSTEROWICZ, John , FANTIN, Valeria R. , SUN, Daqing , YE, Qiuping , MOORE, Jared , ZAVOROTINSKAYA, Tatiana , BLANK, Brian R. , KAWAI, Hiroyuki , YEH, Chien-Hung , REW, Yosup , WU, Kejia , PHAM, Johnny
IPC分类号： C07F9/38 , A61K31/662 , A61P35/00 , A61P31/00 , A61P25/28
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公开(公告)号：EP4337198A1
公开(公告)日：2024-03-20
申请号：EP22808205.3
申请日：2022-05-10
发明人： NDUBAKU, Chudi , MOORE, Jared Thomas , GIBBONS, Paul Anthony , CHANG, Jae Hyuk , ROMERO, F. Anthony , DU, Xiaohui , KAWAI, Hiroyuki , CIBLAT, Stephane , WANG, Hong , ALBERT, Vincent , CONSTANTINEAU-FORGET, Lea , SILVA, Hugo de Almeida , POLAT, Dilan Emine , NAYYAR, Amit , SHORE, Daniel Gordon Michael , WU, Kejia , TAN, Joanne
IPC分类号： A61K31/416
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公开(公告)号：EP3851444A1
公开(公告)日：2021-07-21
申请号：EP21158497.4
申请日：2017-10-06
发明人： SUN, Daqing , MCGEE, Lawrence R. , DU, Xiaohui , ZHU, Liusheng , YAN, Xuelei , REW, Yosup , EKSTEROWICZ, John , MEDINA, Julio C. , FANTIN, Valeria R. , ZHOU, Haiying , BALBAS, Minna Delarae
IPC分类号： C07J17/00 , C07J41/00 , C07J43/00 , C07J51/00 , A61K31/567 , A61K31/569 , A61K31/58 , A61P5/46 , C07J21/00 , C07J31/00 , C07J71/00
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：EP3609872A1
公开(公告)日：2020-02-19
申请号：EP18784078.0
申请日：2018-04-10
发明人： DU, Xiaohui , EKSTEROWICZ, John , FANTIN, Valeria R. , REW, Yosup , SUN, Daqing , YE, Qiuping , ZHOU, Haiying , KAWAI, Hiroyuki , MOORE, Jared , PHAM, Johnny , WU, Kejia , ZHU, Liusheng , YAMASHITA, Dennis
IPC分类号： C07D231/54 , C07D401/06 , C07D417/06 , A61K31/416 , A61P35/00
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公开(公告)号：EP3394079A1
公开(公告)日：2018-10-31
申请号：EP16880126.4
申请日：2016-12-22
发明人： SUN, Daqing , MCGEE, Lawrence R. , DU, Xiaohui , ZHU, Liusheng , YAN, Xuelei , REW, Yosup , EKSTEROWICZ, John , MEDINA, Julio C. , ZHOU, Haiying , BALBAS, Minna Delarae , FANTIN, Valeria R.
IPC分类号： C07J1/00 , C07J41/00 , C07J43/00 , C07J51/00 , A61K31/565 , A61K31/567 , A61K31/58
CPC分类号： C07J43/003 , A61K31/575 , A61K31/58 , A61K45/06 , C07B2200/05 , C07J1/0011 , C07J1/0096 , C07J17/00 , C07J21/006 , C07J21/008 , C07J41/0083 , C07J71/001
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：EP3394078A1
公开(公告)日：2018-10-31
申请号：EP16880121.5
申请日：2016-12-22
发明人： SUN, Daqing , MCGEE, Lawrence R. , DU, Xiaohui , ZHU, Liusheng , YAN, Xuelei , REW, Yosup , EKSTEROWICZ, John , MEDINA, Julio C. , ZHOU, Haiying , BALBAS, Minna Delarae , FANTIN, Valeria R.
IPC分类号： C07J1/00 , C07J31/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J51/00 , A61K31/565 , A61K31/567 , A61K31/58
CPC分类号： C07J51/00 , A61K31/277 , A61K31/473 , A61K31/567 , A61K31/57 , A61K31/58 , A61K45/06 , C07B2200/05 , C07J1/0096 , C07J17/00 , C07J21/006 , C07J31/006 , C07J41/0083 , C07J41/0088 , C07J41/0094 , C07J43/003 , C07J71/001 , A61K2300/00
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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