公开(公告)号：EP0651747A1

公开(公告)日：1995-05-10

申请号：EP94914603.0

申请日：1994-05-11

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： NISHI, Takao ,  UNO, Tetsuyuki ,  SHU, Yoshio ,  TAMURA, Katsumi ,  OKADA, Minoru

IPC分类号： A61K31 ,  A61P7 ,  A61P9 ,  C07D401

CPC分类号： C07D401/12

公开(公告)号：EP1954684B1

公开(公告)日：2014-05-07

申请号：EP06823467.3

申请日：2006-11-14

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： OKADA, Minoru ,  KATO, Masaya ,  SATO, Norifumi ,  UNO, Tetsuyuki ,  KITAGAKI, Hideki ,  HARUTA, Junpei ,  HIYAMA, Hidetaka ,  SHIBATA, Tomonori

IPC分类号： C07D263/34 ,  C07D263/32 ,  C07D413/12 ,  A61K31/422 ,  A61P17/00

CPC分类号： A61K31/421 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  C07D263/32 ,  C07D263/34 ,  C07D413/06 ,  C07D413/12 ,  C12N9/16 ,  C12Y301/04012

摘要： The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by -Y1-A1- or -Y2-C(=O)- wherein Y1 is a group such as -C(=O)-, A1 is a group such as a lower alkylene group, and Y2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

公开(公告)号：EP1954684A2

公开(公告)日：2008-08-13

申请号：EP06823467.3

申请日：2006-11-14

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： OKADA, Minoru ,  KATO, Masaya ,  SATO, Norifumi ,  UNO, Tetsuyuki ,  KITAGAKI, Hideki ,  HARUTA, Junpei ,  HIYAMA, Hidetaka ,  SHIBATA, Tomonori

IPC分类号： C07D263/34 ,  C07D263/32 ,  C07D413/12 ,  A61K31/422 ,  A61P17/00

CPC分类号： A61K31/421 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  C07D263/32 ,  C07D263/34 ,  C07D413/06 ,  C07D413/12 ,  C12N9/16 ,  C12Y301/04012

摘要： The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by -Y1-A1- or -Y2-C(=O)- wherein Y1 is a group such as -C(=O)-, A1 is a group such as a lower alkylene group, and Y2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

公开(公告)号：EP0651747B1

公开(公告)日：1996-03-27

申请号：EP94914603.9

申请日：1994-05-11

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： NISHI, Takao ,  UNO, Tetsuyuki ,  SHU, Yoshio ,  TAMURA, Katsumi ,  OKADA, Minoru

IPC分类号： C07D401/00 ,  A61K31/33

CPC分类号： C07D401/12

摘要： Carbostyril derivatives represented by general formula (1) [wherein, R1 is a hydrogen atom, a fluorine atom or a methyl group; R is a group of formula (a) (R2 is a methyl group, a trifluoromethyl group or a nitro group), or a group of formula (b) (R3 is a fluorine atom and p is an integer of 2 or 3); and n^_ is an integer of 2 or 3], or salts thereof. Said carbostyril derivatives or salts are useful as an agent for inhibiting the adhesion of platelets.