公开(公告)号：EP3186617A4

公开(公告)日：2018-04-25

申请号：EP15835461

申请日：2015-08-26

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： GROT ANNETTE ,  SAXENA RAVI ,  LUNDQUIST PAUL

IPC: G01N21/64 ,  G01N21/77 ,  G02B5/18 ,  G02B5/20 ,  G02B5/28 ,  G02B6/12 ,  G02B6/132 ,  G02B6/136 ,  G02B27/42 ,  H01L27/146

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/78 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2021/7756 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0873 ,  G02B5/1895 ,  G02B5/201 ,  G02B5/285 ,  G02B6/132 ,  G02B6/136 ,  G02B27/4238 ,  G02B27/4244 ,  G02B2006/12102 ,  G02B2006/12109 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14685

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.