公开(公告)号：EP3332032A1

公开(公告)日：2018-06-13

申请号：EP16833794

申请日：2016-08-03

申请人： PACIFIC BIOSCIENCES CALIFORNIA INC

发明人： TURNER STEPHEN ,  KORLACH JONAS ,  WARREN STEVEN

IPC分类号： C12Q1/68 ,  B01L3/00 ,  C12M1/34 ,  G01N27/22 ,  H01L31/109

CPC分类号： C12Q1/6869 ,  B82Y10/00 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  G01N27/4148 ,  G11C19/28 ,  H01L29/0669 ,  H01L29/0673 ,  H01L29/1606

摘要： A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.