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公开(公告)号：EP2755635B1
公开(公告)日：2015-10-14
申请号：EP12745830.5
申请日：2012-08-03
发明人： YAGI, Yukihiro , TANAKA, Masashi , SUGANO, Toshie , SHOJI, Kuniko , SANO, Nao , KELLER, Manfred , HAHN, Michael , EGLE, Roman
IPC分类号： A61K9/19 , A61K31/7036 , A61K47/02 , A61K47/24 , A61P31/04 , C07H15/234
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/19 , A61K31/7036 , A61K47/24 , C07H15/234
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公开(公告)号：EP2755635A1
公开(公告)日：2014-07-23
申请号：EP12745830.5
申请日：2012-08-03
发明人： YAGI, Yukihiro , TANAKA, Masashi , SUGANO, Toshie , SHOJI, Kuniko , SANO, Nao , KELLER, Manfred , HAHN, Michael , EGLE, Roman
IPC分类号： A61K9/08 , A61K31/7036 , A61P31/04 , C07H15/234 , A61K9/00
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/19 , A61K31/7036 , A61K47/24 , C07H15/234
摘要： The invention provides aqueous liquid pharmaceutical compositions comprising arbekacin and chloride ions. The compositions are well tolerable for use in a method for treatment or prevention of a disease of the upper or lower respiratory tract, wherein the composition is aerosolized and inhaled by the patient. Furthermore, the invention provides arbekacin hydrochloride.
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公开(公告)号：EP2194966B1
公开(公告)日：2015-12-02
申请号：EP08801768.6
申请日：2008-08-29
申请人： PARI Pharma GmbH
CPC分类号： A61M11/005 , A61K9/0043 , A61K9/0078 , A61K9/008 , A61K31/7052 , A61M11/00 , A61M15/0085
摘要： A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterised in that it exhibits a low effective flow rate of less than about 5 litres per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.
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公开(公告)号：EP1874270B1
公开(公告)日：2015-08-12
申请号：EP06724092.9
申请日：2006-04-06
申请人： PARI Pharma GmbH
CPC分类号： A61K9/0043 , A61K9/006 , A61K9/007 , A61K9/10 , A61K31/58 , A61K38/13 , A61M11/001 , A61M15/0085
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公开(公告)号：EP2259773B1
公开(公告)日：2013-07-17
申请号：EP09718249.7
申请日：2009-03-05
申请人： PARI Pharma GmbH
发明人： KELLER, Manfred , CORBANIE, Evy
IPC分类号： A61K9/00 , A61K31/7048
CPC分类号： A61K9/0078 , A61K31/7028 , A61K31/7048 , A61K47/12
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公开(公告)号：EP1968538B1
公开(公告)日：2012-04-25
申请号：EP06818907.5
申请日：2006-11-29
申请人： PARI Pharma GmbH
发明人： KELLER, Manfred , AKKAR, Aslihan , Mehrwald, Ralf
CPC分类号： A61K38/13 , A61K9/0014 , A61K9/0078 , A61K9/127 , A61K45/00
摘要： The invention relates to liquid pharmaceutical compositions containing: a) a therapeutically effective dose of a cyclosporin; b) an aqueous carrier liquid; c) a first solubilizing substance selected among the group of phospholipids; and d) a second solubilizing substance selected among the group of non-ionic surfactants. Preferably, the cyclosporin is liposome solubilized. The inventive composition is suitable for oral, parenteral, nasal, mucosal, topical, and particularly pulmonary application in the form of an aerosol.
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公开(公告)号：EP1227856B1
公开(公告)日：2008-08-13
申请号：EP00973900.4
申请日：2000-10-27
申请人： PARI Pharma GmbH
发明人： KNOCH, Martin , KELLER, Manfred , STANGL, Roland , GALLEM, Thomas , LIENING-EWERT, Rainer , URICH, Markus
IPC分类号： A61M15/00
CPC分类号： B05B17/0646 , A61M11/005 , A61M15/0015 , A61M15/0018 , A61M15/0085
摘要： An inhalation nebulizer (1) includes an aerosol generator (2) that has a diaphragm (22) vibrated by a vibration generator (23). The inhalation nebulizer (1) includes a liquid storage container (21) that is in fluid contact with the diaphragm (22). A liquid contained in the storage container (21) is atomized into a mixing chamber (3) through openings in the diaphragm and can subsequently be inhaled by a patient.
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公开(公告)号：EP1874270A2
公开(公告)日：2008-01-09
申请号：EP06724092.9
申请日：2006-04-06
申请人： PARI Pharma GmbH
CPC分类号： A61K9/0043 , A61K9/006 , A61K9/007 , A61K9/10 , A61K31/58 , A61K38/13 , A61M11/001 , A61M15/0085
摘要： Sterile compositions for administration as aerosols are described. They contain an active agent which is poorly water-soluble, a non-ionic surfactant component and a phospholipid component. The compositions are suitable for oral or nasal inhalation, but also for topical or oromucosal administration. They are particulary useful for the efficient pulmonary administration of poorly soluble corticosteroids and can be aerosolized with common nebulizers.
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公开(公告)号：EP2259773A1
公开(公告)日：2010-12-15
申请号：EP09718249.7
申请日：2009-03-05
申请人： PARI Pharma GmbH
发明人： KELLER, Manfred , CORBANIE, Evy
IPC分类号： A61K9/00 , A61K31/7048
CPC分类号： A61K9/0078 , A61K31/7028 , A61K31/7048 , A61K47/12
摘要： The invention provides an aqueous pharmaceutical composition for administration as an aerosol to the respiratory tract, nose or oropharyngeal region comprising (i) a macrolide having a poor taste and poor chemical stability in aqueous solution; (ii) at least one salt selected from the group consisting of sodium gluconate, sodium aspartate, sodium acetate, sodium lactate, sodium succinate, sodium maleate, magnesium gluconate, magnesium aspartate, magnesium citrate, magnesium acetate, magnesium lactate, magnesium succinate, and magnesium maleate; or mixtures thereof and (iii) a taste-masking agent different from said salt; wherein (a) the concentration of said macrolide in the composition is in the range of about 0.25 wt.-% to about 15 wt.-%; (b) the molar ratio of said macrolide : said salt is in the range from about 1 : 0.5 to about 1 : 100; (c) the pH of the composition is in the range of about 3 to 9; and (d) the osmolality of the composition is in the range of about 150 mOsmol/kg to about 1500 mOsmo I/kg. The invention further provides a method of generating an aerosol, preferably by means of a nebuliser, which uses such an aqueous pharmaceutical composition. The macrolide may be used alone or in combination with other drugs. The composition is suitable to treat inflammatory disorders and/or infections of the respiratory tract. It has an improved taste and stability.
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公开(公告)号：EP2194966A1
公开(公告)日：2010-06-16
申请号：EP08801768.6
申请日：2008-08-29
申请人： PARI Pharma GmbH
CPC分类号： A61M11/005 , A61K9/0043 , A61K9/0078 , A61K9/008 , A61K31/7052 , A61M11/00 , A61M15/0085
摘要： A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterised in that it exhibits a low effective flow rate of less than about 5 litres per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.
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