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    Polycyclic ether antibiotics, process for producing them and animal feed compositions containing them
    5.
    发明公开
    Polycyclic ether antibiotics, process for producing them and animal feed compositions containing them 失效
    多环醚抗菌素，其制备方法和含有饲料物质。

    公开(公告)号：EP0000258A1

    公开(公告)日：1979-01-10

    申请号：EP78300057.3

    申请日：1978-06-20

    申请人： PFIZER INC.

    发明人： Celmer, Walter Daniel ,  Cullen, Walter Patrick ,  Moppett, Charles Edward ,  Oscarson, John Richard ,  Huang, Liang Hsiung ,  Shibakawa, Riichiro ,  Tone, Junsuke

    IPC分类号： C12P1/06 ,  C07G11/00 ,  A61K35/66

    CPC分类号： C07G11/00 ,  Y10S435/826

    摘要： Antibiotics 47,433 and 47,434 are produced by culture of Actinomycete micro-organism ATCC 31286, and are useful for controlling coccidiosis in poultry by administration in the diet, and for improving feed utilisation in ruminants and monogastric animals.
    Antibiotic 47,433 as crystalline free acid is soluble in methanol, acetone, chloroform, methylisobutyl ketone, ethyl acetate and insoluble in water; m.p. 89-99°C; (a)D = +16° (C= 1 . 0 , MeOH); average composition by weight: 64.92% carbon, 9.73% hydrogen and 25.35% oxygen (by difference); infrared absorption (KBr pellets, in microns):2.87,3.42, 5.77, 6.85, 7.30. 8.05, 8.60, 9.20, 10.15, 10.53 and 11.45; following crystalline salts are described: -Na(m.p. 226-32°; (a)D --0.2° (C=1.0, MeOH), -K (m.p. 202.-5°; (α) D = -3.2 (C=1.0, MeOH), -Ag (m.p. 180-2°: (α) D = +3.6° (C=1.0, MeOH). Antibiotic 47.434 as crystalline sodium salt is soluble in chloroform, ethyl acetate, methylisobutyl ketone and insoluble in water; m.p. 230-238°C, (α) D = -1.3° (C-1.0, MeOH); infra-red absorption (KBr pellets, in microns): 3.40, 6.40, 6.85, 7.14, 7.27, 7.75, 8.05, 8.40, 8.62, 9.10, 9.40,10.07, 10.50, 11.49.12.65 and 13.25.

    摘要翻译： 抗生素47.433和47.434由ATCC 31286放线菌微生物的培养物中产生，并且是用于在饮食控制由管理在家禽球虫病，以及用于反刍动物和单胃动物提高饲料利用率。 ... 抗生素47.433结晶游离酸可溶于甲醇，丙酮，氯仿，甲基异丁基酮，乙酸乙酯和不溶于水; 熔点 89-99℃; （阿尔法）D = 16°（C = 1.0，甲醇）; 平均组成按重量计：64.92％的碳，9.73％的氢和25.35％的氧气（通过差）; 红外吸收（KBr压片，在微米）：2.87，3.42 5.77，6.85，7.30，8时05分，8.60，9.20，15.10，十点53和11时45; 以下的结晶盐描述：-Na（熔点226-32°（阿尔法）D = -0.2°（C = 1.0，甲醇）-K（熔点202 DEG-5（阿尔法）D = -3.2（C = 1.0，甲醇）-Ag（熔点180-2°（阿尔法）D = 3.6°（C = 1.0，甲醇）抗生素47434作为结晶钠盐可溶于氯仿，乙酸乙酯，甲基异丁基酮和不溶性的。 水;熔点230-238℃，（阿尔法）D = -1.3°（C = 1.0，甲醇）;红外吸收（KBr压片，在微米）：3.40 6.40，6.85，7.14，7.27，7.75，8点05分 ，8.40，8.62，9.10，9时40分，10时07分，10:50 11时49分，12.65和13.25。