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9 条记录 (耗时 0.009 秒)

    Antibiotics and pharmaceutical compositions containing them
    1.
    发明公开
    Antibiotics and pharmaceutical compositions containing them 失效
    抗生素和抗生物药物Zusammensetzungen。

    公开(公告)号：EP0000991A1

    公开(公告)日：1979-03-07

    申请号：EP78300252.0

    申请日：1978-08-16

    申请人： PFIZER INC.

    发明人： Celmer, Walter Daniel ,  Cullen, Walter Patrick ,  Huang, Liang Hsiung ,  Jefferson, Mark Tilden ,  Moppett, Charles Edward ,  Shibakawa, Riichiro ,  Tone, Junsuke

    IPC分类号： C12P1/06 ,  A61K35/66 ,  C07G11/00

    CPC分类号： C07G11/00

    摘要： The invention relates to new antibiotics produced by a new species of Nocardia designated Nocardia argentinensis Huang sp. nov. ATCC 31306. Specific novel antibiotics are designated Compounds 47,444, 47,985 and 48,039, the first of which has been isolated in pure form as an amorphous solid characterised by solubility, elemental analysis, optical rotation, and ultraviolet and infra-red absorption spectra. Antibacterial activity, particularly against normally resistant strains of Staphylococcus aureus, is disclosed.

    摘要翻译： 本发明涉及由诺卡氏菌（Nocardia）新品种诺卡氏菌（Nocardia argentinensis Huang sp。）生产的新型抗生素。 十一月 特定的新型抗生素被指定为化合物47,444,47,985和48,039，其中第一个以纯形式被分离为无定形固体，其特征在于溶解度，元素分析，旋光度和紫外线和红外吸收光谱。 公开了抗菌活性，特别是针对金黄色葡萄球菌的耐药性菌株。

    Salts of penicillanic acid 1,1-dioxide
    7.
    发明公开
    Salts of penicillanic acid 1,1-dioxide 失效
    Penicillansäure-1,1- Dioxid-Salze。

    公开(公告)号：EP0057606A1

    公开(公告)日：1982-08-11

    申请号：EP82300501.2

    申请日：1982-02-01

    申请人： PFIZER INC.

    发明人： Armstrong, William Wellesley ,  Windisch, Wendell William ,  Moppett, Charles Edward

    IPC分类号： C07D499/00 ,  A61K31/43

    CPC分类号： C07D499/00

    摘要： Novel 1:2 N,N'-dibenzylethylenediamine, N-benzyl-2-phenylethylamine and dibenzylamine salts of penicillanic acid 1,1-dioxide are prepared which are sparingly soluble in water and therefore valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals.

    摘要翻译： 新型1：2制备N，N-二苄基乙二胺，N-苄基-2-苯基乙胺和青霉烷酸1,1-二氧化物的二苄胺盐，其微溶于水，因此作为青霉烷酸缓释（贮藏）形式是有价值的 1,1-二氧化物，特别是与哺乳动物细菌感染的化学疗法联用缓释（贮藏）形式的青霉素和头孢菌素抗生素。

    Polycyclic ether antibiotics, process for producing them and animal feed compositions containing them
    9.
    发明公开
    Polycyclic ether antibiotics, process for producing them and animal feed compositions containing them 失效
    多环醚抗菌素，其制备方法和含有饲料物质。

    公开(公告)号：EP0000258A1

    公开(公告)日：1979-01-10

    申请号：EP78300057.3

    申请日：1978-06-20

    申请人： PFIZER INC.

    发明人： Celmer, Walter Daniel ,  Cullen, Walter Patrick ,  Moppett, Charles Edward ,  Oscarson, John Richard ,  Huang, Liang Hsiung ,  Shibakawa, Riichiro ,  Tone, Junsuke

    IPC分类号： C12P1/06 ,  C07G11/00 ,  A61K35/66

    CPC分类号： C07G11/00 ,  Y10S435/826

    摘要： Antibiotics 47,433 and 47,434 are produced by culture of Actinomycete micro-organism ATCC 31286, and are useful for controlling coccidiosis in poultry by administration in the diet, and for improving feed utilisation in ruminants and monogastric animals.
    Antibiotic 47,433 as crystalline free acid is soluble in methanol, acetone, chloroform, methylisobutyl ketone, ethyl acetate and insoluble in water; m.p. 89-99°C; (a)D = +16° (C= 1 . 0 , MeOH); average composition by weight: 64.92% carbon, 9.73% hydrogen and 25.35% oxygen (by difference); infrared absorption (KBr pellets, in microns):2.87,3.42, 5.77, 6.85, 7.30. 8.05, 8.60, 9.20, 10.15, 10.53 and 11.45; following crystalline salts are described: -Na(m.p. 226-32°; (a)D --0.2° (C=1.0, MeOH), -K (m.p. 202.-5°; (α) D = -3.2 (C=1.0, MeOH), -Ag (m.p. 180-2°: (α) D = +3.6° (C=1.0, MeOH). Antibiotic 47.434 as crystalline sodium salt is soluble in chloroform, ethyl acetate, methylisobutyl ketone and insoluble in water; m.p. 230-238°C, (α) D = -1.3° (C-1.0, MeOH); infra-red absorption (KBr pellets, in microns): 3.40, 6.40, 6.85, 7.14, 7.27, 7.75, 8.05, 8.40, 8.62, 9.10, 9.40,10.07, 10.50, 11.49.12.65 and 13.25.

    摘要翻译： 抗生素47.433和47.434由ATCC 31286放线菌微生物的培养物中产生，并且是用于在饮食控制由管理在家禽球虫病，以及用于反刍动物和单胃动物提高饲料利用率。 ... 抗生素47.433结晶游离酸可溶于甲醇，丙酮，氯仿，甲基异丁基酮，乙酸乙酯和不溶于水; 熔点 89-99℃; （阿尔法）D = 16°（C = 1.0，甲醇）; 平均组成按重量计：64.92％的碳，9.73％的氢和25.35％的氧气（通过差）; 红外吸收（KBr压片，在微米）：2.87，3.42 5.77，6.85，7.30，8时05分，8.60，9.20，15.10，十点53和11时45; 以下的结晶盐描述：-Na（熔点226-32°（阿尔法）D = -0.2°（C = 1.0，甲醇）-K（熔点202 DEG-5（阿尔法）D = -3.2（C = 1.0，甲醇）-Ag（熔点180-2°（阿尔法）D = 3.6°（C = 1.0，甲醇）抗生素47434作为结晶钠盐可溶于氯仿，乙酸乙酯，甲基异丁基酮和不溶性的。 水;熔点230-238℃，（阿尔法）D = -1.3°（C = 1.0，甲醇）;红外吸收（KBr压片，在微米）：3.40 6.40，6.85，7.14，7.27，7.75，8点05分 ，8.40，8.62，9.10，9时40分，10时07分，10:50 11时49分，12.65和13.25。