公开(公告)号：EP1567559A4

公开(公告)日：2008-04-16

申请号：EP03796378

申请日：2003-11-12

申请人： POLYMER TECHNOLOGY GROUP INC

发明人： WARD ROBERT S ,  MCCREA KEITH R ,  TIAN YUAN

IPC分类号： C08G18/08 ,  A61L27/14 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08F20060101 ,  C08F2/00 ,  C08G18/12 ,  C08G18/28 ,  C08G18/50 ,  C08G18/62 ,  C08G18/67 ,  C08G65/00 ,  C08G65/329 ,  C08G69/08 ,  C08J5/00 ,  C08L53/00

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

公开(公告)号：EP2132242A4

公开(公告)日：2010-12-01

申请号：EP08732116

申请日：2008-03-13

申请人： POLYMER TECHNOLOGY GROUP INC

发明人： PARAKKA JAMES P ,  MCCREA KEITH R ,  WARD ROBERT S

IPC分类号： C08F293/00 ,  G02B1/04

CPC分类号： C08F293/00 ,  A61L15/26 ,  A61L27/18 ,  C08F8/10 ,  C08F8/14 ,  C08F2810/40 ,  C08G77/442 ,  C08G77/452 ,  C08L53/00 ,  C08L83/10 ,  G02B1/043 ,  C08L39/06 ,  C08L83/06 ,  C08L83/04 ,  C08F126/10 ,  C08L2666/02

公开(公告)号：EP1959971A4

公开(公告)日：2010-01-20

申请号：EP06851302

申请日：2006-12-07

申请人： POLYMER TECHNOLOGY GROUP INC

发明人： WARD ROBERT S ,  MCCREA KEITH R ,  TIAN YUAN ,  PARAKKA JAMES P ,  WANG SHANGER

IPC分类号： A61K47/00

CPC分类号： A61K31/785 ,  C08G18/0895 ,  C08G18/2875 ,  C08G18/288 ,  C08G18/44 ,  C08G18/6266

摘要： Polymers having the formula R(LE) x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE) x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.