公开(公告)号：EP1503981A2

公开(公告)日：2005-02-09

申请号：EP03714236.1

申请日：2003-03-18

申请人： Paratek Pharmaceuticals, Inc.

发明人： NELSON, Mark, L. ,  OHEMENG, Kwasi ,  FRECHETTE, Roger ,  ABATO, Paul ,  ASSEFA, Haregewein ,  BANDARAGE, Upul ,  BERNIAC, Joel ,  BHATIA, Beena ,  CHEN, Jackson ,  ISMAIL, Mohamed, Y. ,  KIM, Oak, A. ,  MATHEWS, Jude ,  HONEYMAN, Laura ,  NIHLAWI, Mohammed ,  PEARSON, Andre ,  REDDY, Laxma ,  SHEAHAN, Paul ,  SIZENSKY, Emmanuelle ,  TOURIGNY, Justin ,  VISKI, Peter ,  WARCHOL, Tadeusz ,  AMOO, Victor ,  MECHICHE, Rachid ,  VERMA, Atul K.

IPC分类号： C07C237/26 ,  C07C43/00 ,  C07C49/00

CPC分类号： C07D307/52 ,  C07C237/26 ,  C07C239/18 ,  C07C251/08 ,  C07C251/48 ,  C07C255/25 ,  C07C255/43 ,  C07C255/58 ,  C07C255/59 ,  C07C271/28 ,  C07C271/44 ,  C07C275/34 ,  C07C279/18 ,  C07C281/14 ,  C07C309/61 ,  C07C311/19 ,  C07C311/21 ,  C07C317/48 ,  C07C323/32 ,  C07C323/60 ,  C07C2603/46 ,  C07D207/16 ,  C07D211/58 ,  C07D213/30 ,  C07D213/61 ,  C07D213/65 ,  C07D213/75 ,  C07D239/26 ,  C07D239/30 ,  C07D239/42 ,  C07D261/10 ,  C07D261/18 ,  C07D295/108 ,  C07D295/155 ,  C07D295/215 ,  C07D307/28 ,  C07D307/68 ,  C07D317/54 ,  C07D401/04

摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.