公开(公告)号：EP3488853A1

公开(公告)日：2019-05-29

申请号：EP18193283.1

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ASSEFA, Haregewein ,  BHATIA, Beena ,  DRAPER, Michael ,  MOLNAR, Dennis P. ,  KIM, Oak K. ,  HONEYMAN, Laura

IPC分类号： A61K31/65 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P43/00 ,  C07C237/26

摘要： Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

公开(公告)号：EP2120963B1

公开(公告)日：2018-09-12

申请号：EP07870927.6

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ASSEFA, Haregewein ,  BHATIA, Beena ,  DRAPER, Michael ,  HONEYMAN, Laura ,  MOLNAR, Dennis P. ,  KIM, Oak, K.

IPC分类号： A61K31/65 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P43/00 ,  C07C237/26

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C2603/46

摘要： Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

公开(公告)号：EP1807387A2

公开(公告)日：2007-07-18

申请号：EP05824836.0

申请日：2005-10-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： ABATO, Paul ,  ASSEFA, Haregewein ,  BERNIAC, Joel ,  BHATIA, Beena ,  BOWSER, Todd ,  CHEN, Jackson ,  GRIER, Mark ,  HONEYMAN, Laura ,  ISMAIL, Mohamed, Y. ,  NELSON, Mark ,  KWASI, Ohemeng ,  PAN, Jingwen

IPC分类号： C07C237/26 ,  C07D295/155 ,  C07D307/54 ,  C07D405/06 ,  A61K31/65 ,  A61P25/28 ,  A61P31/04 ,  A61P31/12 ,  A61P33/06

CPC分类号： C07D471/04 ,  C07C237/26 ,  C07C251/48 ,  C07C255/59 ,  C07C259/10 ,  C07C271/18 ,  C07C271/22 ,  C07C271/24 ,  C07C2601/02 ,  C07C2603/46 ,  C07D207/335 ,  C07D207/337 ,  C07D211/70 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D277/28 ,  C07D277/30 ,  C07D295/096 ,  C07D295/155 ,  C07D295/192 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D309/14 ,  C07D333/20 ,  C07D333/24 ,  C07D333/38 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D413/12 ,  C07D487/04

摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

公开(公告)号：EP1503981A2

公开(公告)日：2005-02-09

申请号：EP03714236.1

申请日：2003-03-18

申请人： Paratek Pharmaceuticals, Inc.

发明人： NELSON, Mark, L. ,  OHEMENG, Kwasi ,  FRECHETTE, Roger ,  ABATO, Paul ,  ASSEFA, Haregewein ,  BANDARAGE, Upul ,  BERNIAC, Joel ,  BHATIA, Beena ,  CHEN, Jackson ,  ISMAIL, Mohamed, Y. ,  KIM, Oak, A. ,  MATHEWS, Jude ,  HONEYMAN, Laura ,  NIHLAWI, Mohammed ,  PEARSON, Andre ,  REDDY, Laxma ,  SHEAHAN, Paul ,  SIZENSKY, Emmanuelle ,  TOURIGNY, Justin ,  VISKI, Peter ,  WARCHOL, Tadeusz ,  AMOO, Victor ,  MECHICHE, Rachid ,  VERMA, Atul K.

IPC分类号： C07C237/26 ,  C07C43/00 ,  C07C49/00

CPC分类号： C07D307/52 ,  C07C237/26 ,  C07C239/18 ,  C07C251/08 ,  C07C251/48 ,  C07C255/25 ,  C07C255/43 ,  C07C255/58 ,  C07C255/59 ,  C07C271/28 ,  C07C271/44 ,  C07C275/34 ,  C07C279/18 ,  C07C281/14 ,  C07C309/61 ,  C07C311/19 ,  C07C311/21 ,  C07C317/48 ,  C07C323/32 ,  C07C323/60 ,  C07C2603/46 ,  C07D207/16 ,  C07D211/58 ,  C07D213/30 ,  C07D213/61 ,  C07D213/65 ,  C07D213/75 ,  C07D239/26 ,  C07D239/30 ,  C07D239/42 ,  C07D261/10 ,  C07D261/18 ,  C07D295/108 ,  C07D295/155 ,  C07D295/215 ,  C07D307/28 ,  C07D307/68 ,  C07D317/54 ,  C07D401/04

摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

公开(公告)号：EP2109602B1

公开(公告)日：2014-02-12

申请号：EP07867938.8

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ABATO, Paul ,  ASSEFA, Haregewein ,  BERNIAC, Joel ,  BHATIA, Beena ,  BOWSER, Todd ,  GRIER, Mark ,  HONEYMAN, Laura ,  ISMAIL, Mohamed ,  KIM, Oak K. ,  NELSON, Mark ,  PAN, Jingwen ,  VERMA, Atul

IPC分类号： C07D207/50 ,  C07D231/12 ,  C07D239/20 ,  C07D241/12 ,  C07D261/02 ,  C07D261/04 ,  C07D263/32 ,  C07D265/02 ,  C07C237/26 ,  A61K31/65 ,  A61P31/04 ,  A61P33/06

CPC分类号： C07C237/26 ,  C07C2603/46 ,  C07D207/20 ,  C07D207/50 ,  C07D211/14 ,  C07D231/12 ,  C07D239/20 ,  C07D239/26 ,  C07D241/12 ,  C07D261/02 ,  C07D261/04 ,  C07D263/32 ,  C07D265/02 ,  C07D265/30 ,  C07D295/13 ,  C07D307/52

公开(公告)号：EP2120963A2

公开(公告)日：2009-11-25

申请号：EP07870927.6

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ASSEFA, Haregewein ,  BHATIA, Beena ,  DRAPER, Michael ,  HONEYMAN, Laura ,  MOLNAR, Dennis P. ,  KIM, Oak, K.

IPC分类号： A61K31/65 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P43/00 ,  C07C237/26

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C2103/46 ,  C07C2603/46

摘要： Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.

摘要翻译： 方法和组合物的皮肤疾病的治疗（例如，痤疮，酒渣鼻）进行说明。

公开(公告)号：EP1656341A1

公开(公告)日：2006-05-17

申请号：EP04756044.6

申请日：2004-06-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： OHEMENG, Kwasi ,  AMOO, Victor ,  KIM, Oak ,  BOWSER, Todd ,  ASSEFA, Haregewein ,  BHATIA, Beena ,  BERNIAC, Joel ,  CHEN, Jackson ,  GRIER, Mark ,  HONEYMAN, Laura ,  PAN, Jingwen ,  MECHICHE, Rachid

IPC分类号： C07C237/26 ,  A61K31/65

CPC分类号： C07D211/18 ,  C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30 ,  C07C2601/14 ,  C07C2603/46

摘要： The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及9-氨基甲基取代的四环素化合物的前体药物，使用该化合物的方法和含有它们的药物组合物。

公开(公告)号：EP1648859B1

公开(公告)日：2013-02-27

申请号：EP04756012.3

申请日：2004-06-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： NELSON, Mark, L. ,  OHEMENG, Kwasi ,  AMOO, Victor ,  KIM, Oak ,  ABATO, Paul ,  ASSEFA, Haregewein ,  BERNIAC, Joel ,  BHATIA, Beena ,  BOWSER, Todd ,  CHEN, Jackson ,  GRIER, Mark ,  HONEYMAN, Laura ,  ISMAIL, Mohamed, Y. ,  MECHICHE, Rachid ,  MATHEWS, Jude

IPC分类号： C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2603/46

摘要： A compound of Formula I: wherein: X is CHC(R 13 Y'Y), CR 6' R 6 , S, NR 6 , or O; R 2 , R 2' , R 4' , and R 4" are each independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic or a prodrug moiety; R 4 is NR 4' R 4" , alkyl, alkenyl, alkynyl, hydroxyl, halogen, or hydrogen; R 2' , R 3 , R 10 , R 11 and R 12 are each hydrogen or a pro-drug moiety; R 5 is hydroxyl, hydrogen, thiol, alkanoyl, aroyl, alkaroyl, aryl, heteroaromatic, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, alkyl carbonyloxy, or aryl carbonyloxy; R 6 and R 6' are each independently hydrogen, methylene, absent, hydroxyl, halogen, thiol, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl; R 7 is ethyl, perhalogenated alkenyl, substituted pyridinyl, pyrazinyl, furanyl, or pyrazolyl; R 8 is hydrogen, hydroxyl, halogen, thiol, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl; R 9 -CH 2 NR 9a R 9b ; R 9a and R 9b are each independently hydrogen, alkyl, alkenyl or linked to form a heterocycle; R 13 is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl; and Y' and Y are each independently hydrogen, halogen, hydroxyl, cyano, sulfhydryl, amino, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2109602A2

公开(公告)日：2009-10-21

申请号：EP07867938.8

申请日：2007-12-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ABATO, Paul ,  ASSEFA, Haregewein ,  BERNIAC, Joel ,  BHATIA, Beena ,  BOWSER, Todd ,  GRIER, Mark ,  HONEYMAN, Laura ,  ISMAIL, Mohamed ,  KIM, Oak K. ,  NELSON, Mark ,  PAN, Jingwen ,  VERMA, Atul

IPC分类号： C07D207/50 ,  C07D231/12 ,  C07D239/20 ,  C07D241/12 ,  C07D261/02 ,  C07D261/04 ,  C07D263/32 ,  C07D265/02 ,  C07C237/26 ,  A61K31/65 ,  A61P31/04 ,  A61P33/06

CPC分类号： C07C237/26 ,  C07C2603/46 ,  C07D207/20 ,  C07D207/50 ,  C07D211/14 ,  C07D231/12 ,  C07D239/20 ,  C07D239/26 ,  C07D241/12 ,  C07D261/02 ,  C07D261/04 ,  C07D263/32 ,  C07D265/02 ,  C07D265/30 ,  C07D295/13 ,  C07D307/52

摘要： The present invention pertains, at least in part, to a substituted tetracycline compound of Formula (I): wherein X is CHC(R13VY), CR6 R6, C=CR6 R6, S, NR6, or O; E is NR7dR7β, OR7f or (CH2)o.iC(=W)WR7s; W is O, S, NR711 or CR75R7*; W is O, S or NR7*; These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.

公开(公告)号：EP1910273A2

公开(公告)日：2008-04-16

申请号：EP06788310.8

申请日：2006-07-21

申请人： Paratek Pharmaceuticals, Inc.

发明人： ABATO, Paul ,  ASSEFA, Haregewein ,  BERNIAC, Joel ,  BOWSER, Todd ,  CHEN, Jackson ,  GRIER, Mark ,  HONEYMAN, Laura

IPC分类号： C07C237/26 ,  C07D295/14 ,  A61K31/65 ,  C07D239/26 ,  C07D265/12 ,  C07D307/77 ,  C07F7/08

CPC分类号： C07D295/155 ,  C07C237/26 ,  C07C309/65 ,  C07D207/06 ,  C07D211/14 ,  C07D239/26 ,  C07D263/58 ,  C07D265/12 ,  C07D307/77 ,  C07D307/81

摘要： 10-Substituted tetracycline compounds are described.