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公开(公告)号：EP2289871A1
公开(公告)日：2011-03-02
申请号：EP10183426.5
申请日：2001-06-29
发明人： Nelson, Mark L. , Frechette, Roger , Viski, Peter , Ismail, Mohamed , Bowser, Todd , Bhatia, Beena , Messersmith, David , McIntyre, Laura , Koza, Darrell , Rennie, Glen , Sheahan, Paul , Hawkins, Paul , Verma, Atul , Warchol, Tad , Bandarage, Upul
IPC分类号： C07C237/26 , C07C311/06 , A61K31/65
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其它已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：EP2345637A3
公开(公告)日：2012-02-15
申请号：EP11161936.7
申请日：2003-07-14
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07C237/26 , A61K31/65 , C07D265/12 , C07D317/54 , Y02A50/411
摘要： The present invention pertains to novel 3, 10 and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression. Methods of preparing the novel 3, 10 and/or 12a-substituted tetracycline compounds are also disclosed.
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