公开(公告)号：EP2470660A1

公开(公告)日：2012-07-04

申请号：EP10812381.1

申请日：2010-08-27

申请人： Pastoral Greenhouse Gas Research Ltd

发明人： ALTERMANN, Eric Heinz ,  ATTWOOD, Graeme Trevor ,  COOK, Gregory ,  DEY, Debjit ,  FERGUSON, Scott A. ,  JANSSEN, Petrus Hendricus ,  KELLY, William John ,  KONG, Zhanhao ,  LAMBIE, Suzanne ,  LEAHY, Sinead Christine ,  LI, Dong ,  MCMILLAN, Duncan ,  MCTAVISH, Sharla ,  PACHECO, Diana ,  RONIMUS, Robert Starr ,  SANG, Carrie ,  YEOMAN, Carl

IPC分类号： C12N15/31 ,  C07K14/195 ,  C07K16/12

CPC分类号： A61K39/0001 ,  A61K2039/552 ,  C07K14/195 ,  C07K16/1267 ,  C12N15/74 ,  G01N2333/195

摘要： The present invention includes the complete genome sequence for the methanogen, Methanobrevibacter ruminantium, including polynucleotides which encode M. ruminantium polypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encoded M. ruminantium polypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such as M. ruminantium cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.