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公开(公告)号：EP2393832A1
公开(公告)日：2011-12-14
申请号：EP10705010.6
申请日：2010-02-05
摘要： The invention relates to the fields of protein chemistry, biology and medicine. More specifically, it relates to the design and preparation of proteinmimics of members of the cystine-knot growth factor superfamily. Further the invention relates to the use of these proteinmimics as a medicament or prophylactic agent. The invention provides proteinmimics of members of the cystine-knot growth factor superfamily, preferably for use in immunogenic and/or therapeutic compositions.
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公开(公告)号：EP2393832B1
公开(公告)日：2015-07-08
申请号：EP10705010.6
申请日：2010-02-05
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公开(公告)号：EP2121007A1
公开(公告)日：2009-11-25
申请号：EP07858126.1
申请日：2007-12-21
发明人： HUBER, Adrian , BACHMANN, Martin , JENNINGS, Gary , TISSOT, Alain , LANGEDIJK, Johannes , TIMMERMAN, Peter , SLOOTSTRA, Jelle , BOSHUIZEN, Ronald
CPC分类号： A61K39/0005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/60 , A61K2039/6075 , A61K2039/62 , A61K2039/64 , C12N2740/16011 , C12N2740/16034 , C12N2795/18123 , C12N2795/18142
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biologyand virology. The invention provides composition comprising a virus-like particle (VLP) linked to atleast one antigen, wherein said antigen is CCR5 PNt domain comprising one looped peptidic structure. The invention also provides a process for producing the composition. The compositions ofthis invention are useful in the production of vaccines, in particular, for the prevention and treatment of HIV infection. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
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