公开(公告)号：EP4365184A1

公开(公告)日：2024-05-08

申请号：EP22833331.6

申请日：2022-07-01

申请人： Peptistar Inc. ,  Sekisui Medical Co., Ltd.

发明人： NEMOTO, Yoshitaka ,  ABE, Hitoshi ,  MORI, Toshihiro

IPC分类号： C07K1/04 ,  C07K1/16 ,  C07K2/00 ,  B01D15/32 ,  B01D15/40 ,  B01D15/42 ,  G01N30/02 ,  G01N30/26 ,  G01N30/88

CPC分类号： Y02P20/54 ,  B01D15/32 ,  B01D15/40 ,  B01D15/42 ,  C07K1/04 ,  G01N30/02 ,  G01N30/88 ,  C07K2/00 ,  C07K1/16 ,  G01N30/26

摘要： To provide a means capable of simultaneously and accurately analyzing a component derived from a carrier for liquid phase peptide synthesis with, for example, a target peptide.
A method for simultaneously analyzing a carrier for liquid phase peptide synthesis, a component derived from the carrier for liquid phase peptide synthesis, an amino acid to which the carrier for liquid phase peptide synthesis is bound, and a peptide compound to which the carrier for liquid phase peptide synthesis is bound, with a target peptide or final target peptide, the analysis method using high-performance liquid chromatography or supercritical fluid chromatography using an alcohol as an eluent.

公开(公告)号：EP3489245A1

公开(公告)日：2019-05-29

申请号：EP17834239.0

申请日：2017-07-24

申请人： Sekisui Medical Co., Ltd.

发明人： YANO, Shinya ,  MORI, Toshihiro ,  KUBOTA, Hideki

IPC分类号： C07F7/18 ,  C07B51/00 ,  C07K1/08

摘要： To develop a protecting group that facilitates separation and purification, after reaction, of a compound including a protected functional group, without solidifying or insolubilizing the compound.
A xanthene compound of by General Formula (1)

(wherein Y is -OR 17 (R 17 is a hydrogen atom or an active ester-protecting group), -NHR 18 (R 18 is a hydrogen atom, or a linear or branched C 1 -C 6 alkyl group or aralkyl group), an azide, a halogen atom, or a carbonyl group formed together with a methylene group;
at least one of R 1 to R 8 is represented by Formula (2);

        -O-R 9 -X-A     (2)

and a residue is a hydrogen atom, a halogen atom, a C 1 -C4 alkyl group, or a C 1 -C 4 alkoxy group,
wherein R 9 is a linear or branched C 1 -C 16 alkylene group;
X is O or CONR 19 (R 19 is a hydrogen atom or a C 1 -C 4 alkyl group); and
A is represented by Formula (3) or the like

(wherein R 10 , R 11 , and R 12 , the same or different, are a linear or branched C 1 -C 6 alkyl group or an aryl group optionally including a substituent;
R 13 is a single bond or a linear or branched C 1 -C 3 alkylene group; and
R 14 , R 15 , and R 16 are a linear or branched C 1 -C 3 alkylene group)).