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公开(公告)号：EP3323070A1
公开(公告)日：2018-05-23
申请号：EP16825179.1
申请日：2016-07-14
IPC分类号： G06F19/22 , G01N33/569 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C40B30/02 , G01N33/574 , G01N2333/70539 , G06F19/00 , G06F19/18 , G16H10/40
摘要： Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self-similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.
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公开(公告)号：EP4407622A2
公开(公告)日：2024-07-31
申请号：EP24167053.8
申请日：2016-07-14
IPC分类号： G16B20/20
CPC分类号： G16H10/40 , G01N33/6878 , G01N33/57484 , C12Q1/6886 , G01N33/574 , G01N2333/7053920130101 , C12Q2600/15620130101 , C12Q2600/13620130101 , G16B20/00 , G16B35/20 , G16B20/20 , G16B20/40
摘要： Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self- similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.
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