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    PYRIDONE-FUSED AZABICYCLIC- OR CYTISINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN ADDICTION THERAPY
    2.
    发明授权
    PYRIDONE-FUSED AZABICYCLIC- OR CYTISINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN ADDICTION THERAPY 失效
    吡啶酮简明AZABICYCLISCHE-或金雀花碱衍生物，生产和使用戒毒

    公开(公告)号：EP0937077B1

    公开(公告)日：2006-05-17

    申请号：EP97942166.6

    申请日：1997-10-15

    申请人： PFIZER INC.

    发明人： O'NEILL, Brian, Thomas

    IPC分类号： C07D471/18 ,  A61K31/44 ,  A61K31/445 ,  A61K31/455 ,  C07D221/00

    CPC分类号： C07D471/18

    摘要： Pyridone-fused azabicyclic compounds of formula (I), and their pharmaceutically acceptable salts and prodrugs, wherein R?1, R2 and R3¿ are defined below, intermediates and methods for their preparation. Compositions and methods for using compounds of formula (I) in the treatment of neurological and mental disorders related to a decrease in cholinergic function such as nicotine addiction, Huntington's Chorea, tardive dyskinesia, hyperkinesia, mania, dyslexia, schizophrenia, analgesia, attention deficit disorder (ADD), multi-infarct dementia, age related cognitive decline, epilepsy, neurological and mental disorders related to a decrease in cholinergic function, senile dementia of the Alzheimer's type, Parkinson's disease, attention deficit hyperactivity disorder (ADHD), anxiety, obesity, Tourette's Syndrome and ulcerative colitis.

    AZANORBORNANE DERIVATIVES
    4.
    发明授权
    AZANORBORNANE DERIVATIVES 失效
    AZANORBORNANDERIVATE

    公开(公告)号：EP0591333B1

    公开(公告)日：1997-03-05

    申请号：EP92913342.9

    申请日：1992-06-11

    申请人： PFIZER INC.

    发明人： O'NEILL, Brian, Thomas

    IPC分类号： C07D487/08

    CPC分类号： C07D487/08 ,  C07D207/14

    摘要： The present invention relates to novel azanorbornane derivatives having formula (I), wherein R1 through R12 are as defined in the description, and to novel intermediates used in their synthesis. The compounds having formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

    PYRIDONE-FUSED AZABICYCLIC- OR CYTISINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN ADDICTION THERAPY
    5.
    发明公开
    PYRIDONE-FUSED AZABICYCLIC- OR CYTISINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN ADDICTION THERAPY 失效
    吡啶酮简明AZABICYCLISCHE-或金雀花碱衍生物，生产和使用戒毒

    公开(公告)号：EP0937077A1

    公开(公告)日：1999-08-25

    申请号：EP97942166.0

    申请日：1997-10-15

    申请人： PFIZER INC.

    发明人： O'NEILL, Brian, Thomas

    IPC分类号： A61K31 ,  A61P1 ,  A61P3 ,  A61P25 ,  A61P43 ,  C07D471

    CPC分类号： C07D471/18

    摘要： Pyridone-fused azabicyclic compounds of formula (I), and their pharmaceutically acceptable salts and prodrugs, wherein R?1, R2 and R3¿ are defined below, intermediates and methods for their preparation. Compositions and methods for using compounds of formula (I) in the treatment of neurological and mental disorders related to a decrease in cholinergic function such as nicotine addiction, Huntington's Chorea, tardive dyskinesia, hyperkinesia, mania, dyslexia, schizophrenia, analgesia, attention deficit disorder (ADD), multi-infarct dementia, age related cognitive decline, epilepsy, neurological and mental disorders related to a decrease in cholinergic function, senile dementia of the Alzheimer's type, Parkinson's disease, attention deficit hyperactivity disorder (ADHD), anxiety, obesity, Tourette's Syndrome and ulcerative colitis.