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    HUMAN MONOCLONAL ANTIBODIES TO INTERLEUKIN-5 AND METHODS AND COMPOSITIONS COMPRISING SAME
    4.
    发明授权
    HUMAN MONOCLONAL ANTIBODIES TO INTERLEUKIN-5 AND METHODS AND COMPOSITIONS COMPRISING SAME 有权
    人类单克隆抗体的白细胞介素-5和这种全面的方法和组合物

    公开(公告)号：EP1527100B1

    公开(公告)日：2009-07-01

    申请号：EP03716836.6

    申请日：2003-03-27

    申请人： Schering Corporation ,  Abgenix, Inc.

    发明人： GREENFEDER, Scott ,  CORVALAN, Jose

    IPC分类号： C07K16/24 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  A61K39/395

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to interleukin 5 (IL-5), which is preferably human IL-5. The invention also relates to human anti-IL-5 antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IL-5 antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IL-5 antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IL-5 antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.

    HUMAN MONOCLONAL ANTIBODIES TO INTERLEUKIN-5 AND METHODS AND COMPOSITIONS COMPRISING SAME
    6.
    发明公开
    HUMAN MONOCLONAL ANTIBODIES TO INTERLEUKIN-5 AND METHODS AND COMPOSITIONS COMPRISING SAME 有权
    人类单克隆抗体的白细胞介素-5和这种全面的方法和组合物

    公开(公告)号：EP1527100A2

    公开(公告)日：2005-05-04

    申请号：EP03716836.6

    申请日：2003-03-27

    申请人： SCHERING CORPORATION ,  Abgenix, Inc.

    发明人： GREENFEDER, Scott ,  CORVALAN, Jose

    IPC分类号： C07K16/24 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  A61K39/395

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to interleukin 5 (IL-5), which is preferably human IL-5. The invention also relates to human anti-IL-5 antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IL-5 antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IL-5 antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IL-5 antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.