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1.发明公开PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开PRODRUGS VON SUBSTITUIERTEN POLYZYCLISCHEN VEBINDUNGENFÜRDIE SELEKTIVE HEMMUNG DER KOAGULATIONSKASKADE
公开(公告)号：EP1482940A2
公开(公告)日：2004-12-08
申请号：EP02773700.6
申请日：2002-10-03
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping
IPC分类号： A61K31/4965 , C07D241/20 , C07D413/12 , A61K31/497 , C07D407/12 , C07D471/04 , C07D401/12
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及包含被衍生的脒取代的5-或6-元杂环或芳环的前药化合物，以及可用于预防和治疗哺乳动物血栓形成状况的组合物和方法。 本发明的前药化合物选择性地抑制凝血级联的某些蛋白酶。
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2.发明公开6-MEMBERED UNSATURATED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OFTHE COAGULATION CASCADE 审中-公开6-GLIEDRIGEUNGESÄTTIGTEHETEROCYCLEN VERWENDBARFÜRSELEKTIVE HEMMUNG DER COAGULATIONSKASKADE
公开(公告)号：EP1448534A1
公开(公告)日：2004-08-25
申请号：EP02800488.5
申请日：2002-10-03
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J. , ZENG, Qingping , ABBAS, Zaheer , FENTON, Ricky L. , KUSTURIN, Carrie L. , HAYAT, Rahman K. , SAMPLE, Kirby R. , SCHWEITZER, Barbara A. , WOOD, Rhonda S. , SZALONY, Jim , SULEYMANOV, Osman D. , SALYERS, Anita , NICHOLSON, Nancy S.
IPC分类号： C07D239/47 , C07D241/20 , C07D403/12 , C07D409/12 , C07D401/12 , C07D403/10 , C07D403/04 , C07D471/04 , A61K31/4965 , A61K31/513 , A61P7/02
CPC分类号： C07D231/38 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成状况的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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3.发明公开6-MEMBERED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开6-元杂环的化合物其中用于选择性抑制凝血级联SUITABLE
公开(公告)号：EP1438292A1
公开(公告)日：2004-07-21
申请号：EP02800484.4
申请日：2002-10-03
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffery, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC分类号： C07D211/98 , A61K31/45 , C07D239/22 , C07D239/10 , C07D253/06 , C07D211/56 , C07D241/04 , C07D213/73 , C07D237/02 , A61K31/535 , A61K31/495 , A61P7/02
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，组合物以及预防和治疗哺乳动物的血栓形成病症的方法。 本发明的前药的化合物，以及它们的，选择性地抑制凝血级联的蛋白酶的某些。
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4.发明公开SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE 审中-公开替代品FÜNFGLIEDRIGEPOLYZYCLISCHEN VEBINDUNGENFÜRDIE SELEKTIVE HEMMUNG DER KOAGULATIONSKASKADE
公开(公告)号：EP1432687A2
公开(公告)日：2004-06-30
申请号：EP02807360.9
申请日：2002-10-03
发明人： SOUTH, Michael, S. , WEBBER, Ronald, K. , HUANG, Horng-Chih , TOTH, Mihaly, V. , MOORMANN, Alan, E. , SNYDER, Jeffrey, S. , SCHOLTEN, Jeffrey, A. , GARLAND, Danny, J. , RUEPPEL, Melvin, L. , NEUMANN, William, L. , LONG, Scott , WEI, Huang , TRUJILLO, John , PARLOW, John, J. , JONES, Darin, E. , CASE, Brenda , HAYES, Michael, J.
IPC分类号： C07D231/00
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to substituted 5-membered polycyclic compounds and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成状况的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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