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公开(公告)号：EP1381359A1
公开(公告)日：2004-01-21
申请号：EP02727562.7
申请日：2002-04-15
发明人： BALLINARI, Dario , BONOMINI, Luisella , ERMOLI, Antonella , GUDE, Markus , MENICHINCHERI, Maria , MOLL, Jurgen , VANOTTI, Ermes
IPC分类号： A61K31/34 , C07D307/86 , A61P35/00
CPC分类号： C07D405/06 , A61K31/343 , A61K45/06 , C07D307/86 , C07D407/06 , C07D409/06 , A61K2300/00
摘要： The present invention relates to know and novel substituted aurones active as telomerase inhibitors, to their use as therapeutic agents, in particular as antitumoral agents, to a process for their preparation as to pharmaceutical compositions comprising them.
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2.发明公开PAK5 A MEMBER OF THE P21-ACTIVATED KINASE (PAK) PROTEIN FAMILY, NUCLEIC ACIDS AND METHODS RELATED TO THE SAME 审中-公开THE P21活化激酶PAK5的构件（PAK）蛋白家族和相关程序
公开(公告)号：EP1244774A2
公开(公告)日：2002-10-02
申请号：EP00981227.2
申请日：2000-11-14
发明人： DAHLBERG, Mats , MOLL, Jurgen , GALVANI, Arturo
IPC分类号： C12N9/00
CPC分类号： C12N9/1205 , A61K39/00 , C12Y207/01037
摘要： The present invention provides a human polypeptide homolog of P21-activated kinase (PAK) polynucleotides which identify and encode PAK5 serine/threonine kinase. In addition, the inventon provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of PAK5 agonists/antagonists, useful for the treatment of human diseases and conditions.
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公开(公告)号：EP1644376A1
公开(公告)日：2006-04-12
申请号：EP04763132.0
申请日：2004-07-08
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D487/04
摘要： Pyrrolo[3,4-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：EP1373244A2
公开(公告)日：2004-01-02
申请号：EP02732481.3
申请日：2002-03-12
发明人： BARGIOTTI, Alberto , BONOMINI, Luisella , MENICHINCHERI, Maria , MOLL, Jurgen , POLUCCI, Paolo , SONCINI, Chiara , VANOTTI, Ermes
IPC分类号： C07D311/30 , C07F7/18 , A61K31/35
CPC分类号： C07D405/04 , A61K31/352 , C07D311/30 , C07D413/04 , C07D417/04
摘要： The present invention relates to benzopyranone derivative, to methods for treating telomerase-modulated diseases, in particular cancers, with said derivatives, to a process for their preparation, to their use as medicaments and to pharmaceutical compositions comprising them.
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