公开(公告)号：EP2788752B1

公开(公告)日：2018-10-03

申请号：EP12855900.2

申请日：2012-12-05

申请人： Pierian Holdings, Inc.

发明人： KULLER, Anne ,  LEE, Tani Ann T. ,  HAZRAR, Saswati ,  KIRKLAND, Richard ,  LIU, Xinjun ,  KIM, Phillip

IPC分类号： G01N33/574 ,  G01N33/542

CPC分类号： G01N33/57484 ,  G01N33/542 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2800/52

摘要： The present invention provides methods for detecting, measuring and quantitating the expression and activation states of signal transduction analytes in cells such as tumor cells. The invention also provides methods for selecting therapy, optimizing therapy, monitoring therapeutic efficacy, and/or detecting therapeutic resistance. Accordingly, the methods are useful for improving cancer therapy selection and disease monitoring.

公开(公告)号：EP2430443B1

公开(公告)日：2018-06-27

申请号：EP10720095.8

申请日：2010-05-13

申请人： Pierian Holdings, Inc.

发明人： KIM, Phillip ,  LIU, Xinjun ,  KIRKLAND, Richard ,  LEE, Tani ,  YBARRONDO, Belen ,  SINGH, Sharat

IPC分类号： G01N33/50 ,  G01N33/532 ,  G01N33/533 ,  G01N33/535 ,  G01N33/543 ,  G01N33/574

CPC分类号： G01N33/57415 ,  G01N33/5011 ,  G01N2800/52

摘要： The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.