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公开(公告)号：EP2954068B8
公开(公告)日：2018-10-31
申请号：EP14706699.7
申请日：2014-02-04
发明人： SINGH, Sharat , KIM, Phillip , LOCKTON, Steven
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N33/57423 , G01N33/5748 , G01N2333/71 , G01N2333/82 , G01N2800/52
摘要： The present invention provides methods for selecting a suitable anticancer drug for the treatment of patient with non-small cell lung cancer (NSCLC). The present invention also provides methods for determining drug resistance in NSCLC patients receiving EGFR inhibitor therapy.
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公开(公告)号：EP3373010A1
公开(公告)日：2018-09-12
申请号：EP18168596.7
申请日：2014-05-21
发明人： KIM, Phillip , JAIN, Anjali , SINGH, Sharat
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , A61K39/00 , A61K2039/505 , G01N33/57492 , G01N2333/70596 , G01N2333/912 , G01N2333/91205 , G01N2333/91215 , G01N2440/14 , G01N2800/52 , G01N2800/54
摘要： The present invention provides assays and methods for predicting the survival of a subject having colorectal cancer (CRC), thereby determining whether the subject will have a good prognosis or poor prognosis. The present invention also provides assays and methods for predicting therapeutic efficacy and/or response to anti-cancer therapeutics in a subject having CRC, thereby selecting a therapeutic regimen to which the subject is likely to be responsive.
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公开(公告)号：EP2430443B1
公开(公告)日：2018-06-27
申请号：EP10720095.8
申请日：2010-05-13
发明人： KIM, Phillip , LIU, Xinjun , KIRKLAND, Richard , LEE, Tani , YBARRONDO, Belen , SINGH, Sharat
IPC分类号： G01N33/50 , G01N33/532 , G01N33/533 , G01N33/535 , G01N33/543 , G01N33/574
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
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4.发明授权
公开(公告)号：EP2999966B1
公开(公告)日：2018-04-25
申请号：EP14728658.7
申请日：2014-05-21
发明人： KIM, Phillip , JAIN, Anjali , SINGH, Sharat
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , A61K39/00 , A61K2039/505 , G01N33/57492 , G01N2333/70596 , G01N2333/912 , G01N2333/91205 , G01N2333/91215 , G01N2440/14 , G01N2800/52 , G01N2800/54
摘要： The present invention provides assays and methods for predicting the survival of a subject having colorectal cancer (CRC), thereby determining whether the subject will have a good prognosis or poor prognosis. The present invention also provides assays and methods for predicting therapeutic efficacy and/or response to anti-cancer therapeutics in a subject having CRC, thereby selecting a therapeutic regimen to which the subject is likely to be responsive.
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5.发明授权
公开(公告)号：EP2694972B8
公开(公告)日：2017-08-16
申请号：EP12716858.1
申请日：2012-04-04
发明人： KIM, Phillip , SINGH, Sharat
IPC分类号： G01N33/574
CPC分类号： G01N33/6893 , A61K31/517 , A61K31/5377 , A61K45/06 , G01N33/57446 , G01N2333/71 , G01N2800/52 , G01N2800/54 , G01N2800/56
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