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公开(公告)号：EP3581573A1
公开(公告)日：2019-12-18
申请号：EP19189460.9
申请日：2016-05-05
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： The present disclosure provides a process for the preparation of crystalline Form C of Compound II:
comprising:
(1) adding Compound II to from about 0.4% v/v wet methyl tert-butyl ether (MTBE) to about 1.5% v/v wet MTBE to provide a reaction mixture;
(2) refluxing the reaction mixture;
(3) cooling the reaction mixture to about room temperature; and
(4) isolating the crystalline Form C of Compound II from the reaction mixture.-
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3.发明公开SYNTHESIS OF 1 H-PYRROLO[2,3-B]PYRIDIN DERIVATIVES THAT MODULATE KINASES 审中-公开合成调制激酶的1H-吡咯并[2,3-B]吡啶衍生物
公开(公告)号：EP3292122A1
公开(公告)日：2018-03-14
申请号：EP16723224.8
申请日：2016-05-05
IPC分类号： C07D471/04
摘要： or a salt thereof, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：EP3658189A1
公开(公告)日：2020-06-03
申请号：EP18752384.0
申请日：2018-07-24
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公开(公告)号：EP3700574A1
公开(公告)日：2020-09-02
申请号：EP18801185.2
申请日：2018-10-26
申请人： Plexxikon Inc.
IPC分类号： A61K45/06 , A61K9/14 , A61K31/506 , A61K31/5377 , A61P35/04 , A61P35/00 , A61P35/02 , A61K9/16
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公开(公告)号：EP3386980A1
公开(公告)日：2018-10-17
申请号：EP16826214.5
申请日：2016-12-06
申请人： Plexxikon Inc.
发明人： WU, Guoxian , WU, Jeffrey , CHAN, Katrina , DONG, Ken , EWING, Todd , IBRAHIM, Prabha N. , LIN, Jack , SPEVAK, Wayne , ZHANG, Ying
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , C07D491/107
摘要： or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Z2, Z3, and Z5 are as described herein, compositions thereof, and uses thereof.
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7.发明公开PYRROLO [2, 3-B]PYRIDINE DERIVATIVES AS KINASE MODULATORS 审中-公开吡咯并[2,3-B]吡啶衍生物ALS KINASEMULULATOREN
公开(公告)号：EP2097414A1
公开(公告)日：2009-09-09
申请号：EP07855276.7
申请日：2007-12-19
申请人： PLEXXIKON, INC.
发明人： SPEVAK, Wayne , CHO, Hanna , IBRAHIM, Prabha N. , SHI, Shenghua , MAMO, Shumeye , GILLETTE, Sam , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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8.发明公开
公开(公告)号：EP2086972A2
公开(公告)日：2009-08-12
申请号：EP07864681.7
申请日：2007-11-20
申请人： PLEXXIKON, INC.
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
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公开(公告)号：EP3281675A1
公开(公告)日：2018-02-14
申请号：EP17170715.1
申请日：2012-02-21
发明人： DIODONE, Ralph , FAEHNRICH, Karsten , IBRAHIM, Prabha N. , KUANG, Shan-ming , VISOR, Gary Conard , ZHAO, Baoshu , SCHWITTER, Urs
IPC分类号： A61P35/00 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
摘要翻译： 本发明提供了式1化合物的固体形式及其药物用途。
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公开(公告)号：EP3004060A1
公开(公告)日：2016-04-13
申请号：EP14733877.6
申请日：2014-05-29
申请人： PLEXXIKON INC.
发明人： ZHANG, Chao , HIRTH, Klaus-Peter , IBRAHIM, Prabha N. , NESPI, Marika , SHI, Songyuan , SPEVAK, Wayne , HABETS, Gaston G. , BURTON, Elizabeth, A.
IPC分类号： C07D213/75 , C07D417/04 , C07D471/04 , C07D487/04 , A61K31/519
摘要： Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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