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40 条记录 (耗时 0.042 秒)

    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    5.
    发明公开
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
    连接和方法激酶调节和其显示

    公开(公告)号：EP2516438A2

    公开(公告)日：2012-10-31

    申请号：EP10840075.5

    申请日：2010-12-21

    申请人： Plexxikon, Inc.

    发明人： IBRAHIM, Prabha N. ,  WU, Guoxian ,  LIN, Jack ,  SPEVAK, Wayne ,  CHO, Hanna ,  EWING, Todd ,  ZHANG, Chao

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/497 ,  A61K31/498 ,  A61K31/506 ,  A61K31/519 ,  C07D519/00

    摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.