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公开(公告)号：EP1648851B2
公开(公告)日：2011-08-31
申请号：EP04743515.1
申请日：2004-07-23
IPC分类号： C07C51/41
CPC分类号： C07C51/412 , C07C53/126
摘要： A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
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公开(公告)号：EP1648851A2
公开(公告)日：2006-04-26
申请号：EP04743515.1
申请日：2004-07-23
IPC分类号： C07C51/41
CPC分类号： C07C51/412 , C07C53/126
摘要： A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
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公开(公告)号：EP1687297B1
公开(公告)日：2014-06-18
申请号：EP04818743.9
申请日：2004-11-22
发明人： PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
IPC分类号： C07D251/70 , C07D403/14 , C07D403/12 , A61K39/395 , A61K31/53 , A61P37/00
CPC分类号： C07D401/14 , C07D251/70
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公开(公告)号：EP1648851B1
公开(公告)日：2007-04-25
申请号：EP04743515.1
申请日：2004-07-23
IPC分类号： C07C51/41
CPC分类号： C07C51/412 , C07C53/126
摘要： A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
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5.发明公开METHOD FOR THE PREPARATION OF TRIGLYCERIDES OF MEDIUM-CHAIN LENGTH FATTY ACIDS 审中-公开用于生产甘油三酯FROM中链脂肪酸
公开(公告)号：EP2819989A1
公开(公告)日：2015-01-07
申请号：EP13755282.4
申请日：2013-02-28
CPC分类号： C07C67/08 , A61K31/225 , A61K31/23 , A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/14 , C11C3/02 , C11C3/025 , A61K2300/00
摘要： A method is disclosed for the preparation of glycerol esters (triglycerides) of medium-chain length monocarboxylic fatty acids which consists of the reaction of the precursor free fatty acid and glycerol in the presence of a catalyst under partial vacuum. The process preferably uses a metal catalyst such as an oxide or a chloride of tungsten, molybdenum, calcium, zinc, chromium or magnesium. The method of the invention allows the preparation in high yield and high purity (>99.5%) of the final triglyceride. The present method allows the formation of triglycerides without solvent. Are also contemplated, the triglyceride obtained by the method, and the pharmaceutical composition containing the triglyceride as an excipient or as an active ingredient.
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6.发明公开2,4,6-TRIAMINO-S-TRIAZINE-BASED COMPOUNDS WHICH BIND TO THE TAIL (Fc) PORTION OF IMMUNOGLOBULINS AND THEIR USE 审中-公开联结到2,4,6-三氨基-S-三嗪，导致免疫球蛋白结合和其应用的尾部部分（FC-PART）
公开(公告)号：EP1786787A1
公开(公告)日：2007-05-23
申请号：EP05778858.0
申请日：2005-09-02
发明人： PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
IPC分类号： C07D251/54 , A61P37/00 , A61K31/53 , A61M1/36 , A61K31/519 , A61K39/395 , A61K38/17 , C07K16/18 , C07K1/22
CPC分类号： C07D251/70 , A61M1/3679 , C07K16/00 , C07K2317/52
摘要： The present invention comprises new compounds described by the following general formula:(I) NH2 where R is a straight chain or cyclic alkyl group, X is oxygen or sufur or an imino group or is absent, R' is an amino or metoxy group, or fluorine or chlorine atom and n is 0, 1 or 2. These compounds are useful for binding to tail or Fc portion of immunoglobulins and so have utility in those applications which require the non-covalent binding interaction of a molecule with the Fc portion of immunoglobulins. Such applications include the detection and purification of immunoglobulins as well as the treatment of certain autoimmune diseases.
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公开(公告)号：EP1687297A1
公开(公告)日：2006-08-09
申请号：EP04818743.9
申请日：2004-11-22
发明人： PENNEY, Christopher , ZACHARIE, Boulos , ABBOTT, Shaun, D. , BIENVENU, Jean-François , CAMERON, Alan, D. , DUCEPPE, Jean-Simon , EZZITOUNI, Abdallah , FORTIN, Daniel , HOUDE, Karine , MOREAU, Nancie , WILB, Nicole , GROUIX, Brigitte , GAGNON, Lyne
IPC分类号： C07D403/14 , C07D403/12 , A61K39/395 , A61K31/53 , A61P37/00 , A61M1/36 , C07K1/22 , C07K16/24
CPC分类号： C07D401/14 , C07D251/70
摘要： Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this invention include rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic (immune) thrombocytopenia (ITP), glomerulonephritis and vasculitis. The present invention also relates to reducing drug toxicity which often accompanies traditional therapies for autoimmune diseases. The compounds may also be used to bind antibody in vitro or ex vivo.
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