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1.发明公开MEDIUM-CHAIN LENGTH FATTY ACIDS, GLYCERIDES AND ANALOGUES AS NEUTROPHIL SURVIVAL AND ACTIVATION FACTORS 有权Fettsäurenmit mittlererKettenlänge，Glyceride und Analoge als neutrophile Haltbarkeits- und Aktivierungsfaktoren
公开(公告)号：EP1900364A2
公开(公告)日：2008-03-19
申请号：EP07116425.5
申请日：2002-04-18
IPC分类号： A61K31/20
CPC分类号： C07C237/22 , A61K31/18 , A61K31/194 , A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61K38/193 , A61K38/2013 , A61K38/2086 , A61K45/06 , C07B2200/11 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C11C3/003 , C11C3/02 , C40B40/00 , Y02A50/387 , Y02A50/483 , A61K2300/00
摘要： A compound of formula I
wherein A and B are the same or different and are each H or R 1 CO;
R 1 is C 7 -C 11 alkyl; and
Y is 0 or NH;
is useful in stimulating hematopoiesis.摘要翻译： 式I的化合物，其中A和B相同或不同，各自为H或R 1 CO; R 1是C 7 -C 11烷基; Y为0或NH; 可用于刺激造血。
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公开(公告)号：EP1648851A2
公开(公告)日：2006-04-26
申请号：EP04743515.1
申请日：2004-07-23
IPC分类号： C07C51/41
CPC分类号： C07C51/412 , C07C53/126
摘要： A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
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3.发明公开MEDIUM-CHAIN LENGTH FATTY ACIDS, GLYCERIDES AND ANALOGUES AS STIMULATORS OF ERYTHROPOIESIS 有权中链脂肪酸，甘油酯及其类似物作为红细胞生成刺激剂
公开(公告)号：EP1592416A1
公开(公告)日：2005-11-09
申请号：EP04708802.6
申请日：2004-02-06
IPC分类号： A61K31/20
CPC分类号： A61K31/20 , A61K31/23 , A61K45/06 , A61K47/14 , A61K2300/00
摘要： Use of a composition comprising a compound of any of formulae I, II, Ila, III and Illa; or a combination thereof wherein each R1 is independently C7-11 alkyl; A and B are independently H or CO-R1; R2 is H or C1-4 alkyl; M is a metal monocation (k = 1) or dication (k = 2); Y is 0 or NH; and Z is 0, NH, CH2O or a bond; for the manufacture of a medicament for stimulating erythropoiesis. Preferably, the composition further comprises human erythroporietin.
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公开(公告)号：EP2632452A1
公开(公告)日：2013-09-04
申请号：EP11856486.3
申请日：2011-10-26
发明人： GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , LAURIN, Pierre , PENNEY, Christopher , ZACHARIE, Boulos
IPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61P35/00 , C07C217/84 , C07C229/18 , C07C229/42 , C07C229/60 , C07C323/20 , C07C323/52 , C07C323/62 , C07C57/30 , C07C59/52 , C07C59/64 , C07C59/76
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
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公开(公告)号：EP1648851B2
公开(公告)日：2011-08-31
申请号：EP04743515.1
申请日：2004-07-23
IPC分类号： C07C51/41
CPC分类号： C07C51/412 , C07C53/126
摘要： A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
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">6.发明公开"TRIAZINE DERIVATIVES, COMPOSITIONS CONTAINING SUCH DERIVATIVES, AND METHODS OF TREATMENT OF CANCER AND AUTOIMMUNE DISEASES USING SUCH DERIVATIVES" 有权“三嗪衍生物，含有这些衍生物的组合物，以及使用这些衍生物治疗癌症和自身免疫疾病的方法”
公开(公告)号：EP2152676A1
公开(公告)日：2010-02-17
申请号：EP08748198.2
申请日：2008-04-25
发明人： ZACHARIE, Boulos , PENNEY, Christopher , GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , ABBOTT, Shaun, D.
IPC分类号： C07D251/70 , A61K31/53 , A61P35/00 , A61P37/00 , C07D251/18
CPC分类号： C07D251/18 , C07D251/70
摘要： We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.
摘要翻译： 我们描述了以下通式（I）的化合物：其中X是氟或氯; Y是氧，硫或氨基; R是氨基，羟基，磺酰胺或羧酰胺基团或其N-甲基或N-二甲基类似物; m是2至6的整数，且n是0至2的整数。所述化合物可用于治疗某些癌症和自身免疫性疾病。
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7.发明公开SUBSTITUTED PURINYL DERIVATIVES WITH IMMUNOMODULATOR AND CHEMOPROTECTIVE ACTIVITY AND USE ALONE OR WITH MEDIUM-CHAIN LENGTH FATTY ACIDS OR GLYCERIDES 审中-公开取代嘌呤基衍生物的免疫调节和化学预防活动，并使用单独的或与OR中链脂肪酸甘油酯
公开(公告)号：EP1784190A1
公开(公告)日：2007-05-16
申请号：EP05779573.4
申请日：2005-09-02
CPC分类号： A61K31/20 , A61K31/23 , A61K31/417 , A61K31/52 , A61K2300/00
摘要： The present invention describes new biological activities of immunomodulating 6-substituted purinyl compounds which make them particularly useful during the treatment of cancer. Collectively, these new biological activities make these purinyl compounds useful chemoprotective agents for the treatment of myelosuppression which is associated with cancer chemotherapy and/or radiotherapy. This chemoprotective activity is in addition to the immunomodulating and subsequent anticancer activity displayed by these compounds, The chemoprotective usefulness of these compounds is further enhanced by the use of medium-chain fatty acids or salts or triglycerides or mono- or diglycerides in combination with the 6-substituted purinyl compounds of this invention.
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8.发明公开
公开(公告)号：EP1385498A2
公开(公告)日：2004-02-04
申请号：EP02761857.8
申请日：2002-04-18
IPC分类号： A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61P7/06 , A61K31/18 , A61K31/194 , C07H15/04 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C07C237/22
CPC分类号： C07C237/22 , A61K31/18 , A61K31/194 , A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61K38/193 , A61K38/2013 , A61K38/2086 , A61K45/06 , C07B2200/11 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C11C3/003 , C11C3/02 , C40B40/00 , Y02A50/387 , Y02A50/483 , A61K2300/00
摘要： A compound of formula I wherein A and B are the same or different and are each H or R 1 CO; R 1 is C 7 -C 11 alkyl; and Y is 0 or NH; is useful in stimulating hematopoiesis.
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9.发明公开SUBSTITUTED AROMATIC COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, LIVER FIBROSIS, SKIN FIBROSIS AND CARDIAC FIBROSIS 审中-公开取代的芳族化合物用于治疗肺纤维化，肝纤维化，皮肤纤维化及心纤维化
公开(公告)号：EP2970088A1
公开(公告)日：2016-01-20
申请号：EP14762607.1
申请日：2014-03-14
发明人： GAGNON, Lyne , LAURIN, Pierre , GROUIX, Brigitte , GEERTS, Lilianne , SARRA-BOURNET, François , LEDUC, Martin , ABBOTT, Shaun , ZACHARIE, Boulos , BIENVENU, Jean-François , PERRON, Valérie
摘要： The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2—OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH.
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10.发明授权Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors 有权脂肪酸与中链甘油酯和类似物作为嗜中性粒细胞的耐久性和活化因子
公开(公告)号：EP1900364B1
公开(公告)日：2013-09-25
申请号：EP07116425.5
申请日：2002-04-18
IPC分类号： A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61P7/06 , A61K31/18 , A61K31/194 , C07H15/04 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C07C237/22 , A61K38/19 , A61K38/20 , C11C3/00 , C11C3/02
CPC分类号： C07C237/22 , A61K31/18 , A61K31/194 , A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61K38/193 , A61K38/2013 , A61K38/2086 , A61K45/06 , C07B2200/11 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C11C3/003 , C11C3/02 , C40B40/00 , Y02A50/387 , Y02A50/483 , A61K2300/00
摘要： A compound of formula I wherein A and B are the same or different and are each H or R 1 CO; R 1 is C 7 -C 11 alkyl; and Y is 0 or NH; is useful in stimulating hematopoiesis.
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