利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.012 秒)

    METHODS OF TREATMENT USING LIPID COMPOUNDS
    3.
    发明公开
    METHODS OF TREATMENT USING LIPID COMPOUNDS 有权
    治疗与脂类化合物方法

    公开(公告)号：EP2635270A1

    公开(公告)日：2013-09-11

    申请号：EP11837647.4

    申请日：2011-11-03

    申请人： Pronova BioPharma Norge AS

    发明人： HOVLAND, Ragnar ,  SKJÆRET, Tore ,  FRASER, David A.

    IPC分类号： A61K31/19 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  C07C57/03

    CPC分类号： C07C69/734 ,  A61K31/19 ,  A61K31/355 ,  C07C59/60 ,  C07D263/26 ,  A61K2300/00

    摘要： Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I): (I) or a pharmaceutically acceptable salt, or ester thereof, wherein R
    1 and R
    2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C
    1 -C
    6 alkyl groups, with the proviso that R
    1 and R
    2 are not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL- cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol. The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed.

    NEW DHA DERIVATIVES AND THEIR USE AS MEDICAMENTS
    9.
    发明公开
    NEW DHA DERIVATIVES AND THEIR USE AS MEDICAMENTS 审中-公开
    新的DHA衍生物及其作为药物

    公开(公告)号：EP2217558A1

    公开(公告)日：2010-08-18

    申请号：EP08844938.4

    申请日：2008-10-30

    申请人： Pronova Biopharma Norge AS

    发明人： HOLMEIDE, Anne Kristin ,  HOVLAND, Ragnar

    IPC分类号： C07C69/587 ,  C07C69/734 ,  A61K31/19 ,  A61P3/10

    CPC分类号： C07C69/587 ,  C07C67/26 ,  C07C67/28 ,  C07C69/63

    摘要： The present disclosure relates to compounds of the general Formula (I): wherein R1 and R2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and any pharmaceutically acceptable salt, solvate, complex, or pro-drug thereof; and their use as medicaments for the treatment of various diseases and conditions, for example, reduction of elevated triglyceride levels, i.e., hypertriglyceridemia, reduction of non-HDL cholesterol, reduction of glucose and HbAIc, and improvement of insulin resistance. The present disclosure also relates to a pharmaceutical composition comprising compounds of formula (I), as well as to processes for preparing compounds according to formula (I).