公开(公告)号：EP2406256A1

公开(公告)日：2012-01-18

申请号：EP10709926.9

申请日：2010-03-12

申请人： Prosidion Limited

发明人： BARBA, Oscar ,  DAVIS, Susan, Helen ,  FYFE, Matthew, Colin, Thor ,  JEEVARATNAM, Revathy, Perpetua ,  SCHOFIELD, Karen, Lesley ,  STAROSKE, Thomas ,  STEWART, Alan, John, William ,  SWAIN, Simon, Andrew ,  WITHALL, David, Matthew

IPC分类号： C07D413/14 ,  A61K31/4245 ,  A61P3/10

CPC分类号： C07D413/14

摘要： The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.

公开(公告)号：EP2406251A1

公开(公告)日：2012-01-18

申请号：EP10709053.2

申请日：2010-03-12

申请人： Prosidion Limited

发明人： BARBA, Oscar ,  DUPREE, Tom, Banksia ,  FRY, Peter, Timothy ,  FYFE, Matthew, Colin, Thor ,  JEEVARATNAM, Revathy, Perpetua ,  KRULLE, Thomas, Martin ,  SCHOFIELD, Karen, Lesley ,  SMYTH, Donald ,  STAROSKE, Thomas ,  STEWART, Alan, John, William ,  STONEHOUSE, David, French ,  SWAIN, Simon, Andrew ,  WITHALL, David, Matthew

IPC分类号： C07D403/12 ,  A61K31/506 ,  A61P3/10

CPC分类号： C07D403/12

摘要： The present invention is directed to therapeutic compounds of the following formula (I) which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.

摘要翻译： 本发明涉及下式（I）的治疗化合物，其具有作为GPR119激动剂的活性并可用于治疗包括II型糖尿病的代谢病症。

公开(公告)号：EP2114932A1

公开(公告)日：2009-11-11

申请号：EP08700185.5

申请日：2008-01-04

申请人： Prosidion Limited

发明人： FYFE, Matthew, Colin, Thor ,  KEILY, John ,  PROCTER, Martin ,  STONEHOUSE, David, French ,  SWAIN, Simon, Andrew

IPC分类号： C07D413/04 ,  A61K31/454 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D413/04

摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

公开(公告)号：EP2406247A1

公开(公告)日：2012-01-18

申请号：EP10709925.1

申请日：2010-03-12

申请人： Prosidion Limited

发明人： BARBA, Oscar ,  FRY, Peter, Timothy ,  FYFE, Matthew, Colin, Thor ,  GATTRELL, William ,  JEEVARATNAM, Revathy, Perpetua ,  KRULLE, Thomas, Martin ,  PROCTER, Martin, James ,  SAMBROOK-SMITH, Colin, Peter ,  SCHOFIELD, Karen, Lesley ,  SMYTH, Donald ,  STEWART, Alan, John, William ,  STONEHOUSE, David, French ,  SWAIN, Simon, Andrew

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  A61K31/4523 ,  A61K31/397 ,  A61P3/00

CPC分类号： C07D401/12 ,  C07D213/64 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14

摘要： The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes (I).

摘要翻译： 本发明涉及具有GPR119激动剂活性并可用于治疗包括II型糖尿病（I）的代谢病症的治疗性化合物。

公开(公告)号：EP1907384A2

公开(公告)日：2008-04-09

申请号：EP06744357.2

申请日：2006-06-29

申请人： Prosidion Limited

发明人： BRADLEY, Stuart, Edward ,  FYFE, Matthew, Colin, Thor ,  BERTRAM, Lisa, Sarah ,  GATTRELL, William ,  PROCTER, Martin, James ,  RASAMISON, Chrystelle, Marie ,  SAMBROOK-SMITH, Colin, Peter ,  SHAH, Vilasben, Kanji ,  STONEHOUSE, David, French ,  SWAIN, Simon, Andrew ,  THOMAS, Gerard, Hugh

IPC分类号： C07D413/14 ,  C07D471/04 ,  C07D495/04 ,  C07D417/14

CPC分类号： C07D471/04 ,  C07D405/06 ,  C07D405/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

公开(公告)号：EP2114933A1

公开(公告)日：2009-11-11

申请号：EP08702095.4

申请日：2008-01-04

申请人： Prosidion Limited

发明人： FYFE, Matthew, Colin, Thor ,  KEILY, John ,  SWAIN, Simon, Andrew

IPC分类号： C07D413/04 ,  A61K31/454 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D413/04

摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

公开(公告)号：EP2114931A1

公开(公告)日：2009-11-11

申请号：EP08700184.8

申请日：2008-01-04

申请人： Prosidion Limited

发明人： BERTRAM, Lisa, Sarah ,  FYFE, Matthew, Colin, Thor ,  JEEVARATNAM, Revathy, Perpetua ,  KEILY, John ,  SWAIN, Simon, Andrew

IPC分类号： C07D413/04 ,  A61K31/454 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D413/04

摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

公开(公告)号：EP2215077A1

公开(公告)日：2010-08-11

申请号：EP08806784.8

申请日：2008-10-20

申请人： Prosidion Limited

发明人： FYFE, Matthew, Colin, Thor ,  GATTRELL, William ,  SAMBROOK-SMITH, Colin, Peter ,  SWAIN, Simon, Andrew

IPC分类号： C07D401/14 ,  A61K31/435 ,  A61P3/00

CPC分类号： C07D401/12

摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful for the treatment of diabetes and as peripheral regulators of satiety, e.g. for the treatment of obesity and metabolic syndrome.

摘要翻译： 式（I）化合物或其药学上可接受的盐是GPR119的激动剂，并且可用于治疗糖尿病和作为饱腹感的外周调节剂，例如， 用于治疗肥胖和代谢综合征。

公开(公告)号：EP2200609A1

公开(公告)日：2010-06-30

申请号：EP08806639.4

申请日：2008-09-10

申请人： Prosidion Limited

发明人： BARBA, Oscar ,  BRADLEY, Stuart, Edward ,  FYFE, Matthew, Colin, Thor ,  HANRAHAN, Patrick, Eric ,  KRULLE, Thomas, Martin ,  PROCTER, Martin, James ,  REYNET MCCORMACK, Christine ,  SCHOFIELD, Karen, Lesley ,  SMYTH, Donald ,  STEWART, Alan, John, William ,  SWAIN, Simon, Andrew ,  WIDDOWSON, Peter

IPC分类号： A61K31/44 ,  A61P3/04 ,  A61P3/10 ,  C07D401/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D401/12 ,  C07D211/18 ,  C07D211/22 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention is directed to therapeutic compounds which have dual activity as agonists of GPR119 and inhibitors of DPP-IV and are useful for the treatment of metabolic disorders including type II diabetes.

摘要翻译： 本发明涉及具有作为GPR119激动剂和DPP-IV抑制剂双重活性的治疗性化合物，并且可用于治疗包括II型糖尿病的代谢病症。

公开(公告)号：EP2114936A1

公开(公告)日：2009-11-11

申请号：EP08702097.0

申请日：2008-01-04

申请人： Prosidion Limited

发明人： FYFE, Matthew, Colin, Thor ,  JEEVARATNAM, Revathy, Perpetua ,  KEILY, John ,  SWAIN, Simon, Andrew

IPC分类号： C07D413/14 ,  A61K31/454 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D413/14

摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR激动剂，并且可用于治疗肥胖症和糖尿病。