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    MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF
    1.
    发明公开
    MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF 有权
    治疗性蛋白及其使用多聚体形式

    公开(公告)号：EP2542572A2

    公开(公告)日：2013-01-09

    申请号：EP11711151.8

    申请日：2011-03-02

    申请人： Protalix Ltd.

    发明人： RUDERFER, Ilya ,  SHILOVITTZKY, Orit ,  SHULMAN, Avidor ,  SHAALTIEL, Yoseph ,  BEN-MOSHE, Tehila ,  SHEKHTER, Talia ,  AZULAY, Yaniv

    IPC分类号： C07K14/525

    CPC分类号： C07K14/525

    摘要： Multimeric protein structures are disclosed herein, as well a process for preparing same, and methods employing same for treating various diseases or disorders. The multimeric protein structures comprise at least two monomers of a therapeutic protein, including a TNF-alpha, a luteinizing hormone, an immunoglobin, a TNF-alpha receptor, a CTLA-4, a urate oxidase, a VEGF, a PDGF, a VEGF receptor, a PDGF receptor, an interleukin-17, and/or fragments thereof, the monomers being covalently linked to one another via a linking moiety. The multimeric protein structures exhibit improved performance as compared to the corresponding native proteins, including a longer lasting activity in vivo.