利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.029 秒)

    MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF
    2.
    发明公开
    MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF 有权
    治疗性蛋白及其使用多聚体形式

    公开(公告)号：EP2542572A2

    公开(公告)日：2013-01-09

    申请号：EP11711151.8

    申请日：2011-03-02

    申请人： Protalix Ltd.

    发明人： RUDERFER, Ilya ,  SHILOVITTZKY, Orit ,  SHULMAN, Avidor ,  SHAALTIEL, Yoseph ,  BEN-MOSHE, Tehila ,  SHEKHTER, Talia ,  AZULAY, Yaniv

    IPC分类号： C07K14/525

    CPC分类号： C07K14/525

    摘要： Multimeric protein structures are disclosed herein, as well a process for preparing same, and methods employing same for treating various diseases or disorders. The multimeric protein structures comprise at least two monomers of a therapeutic protein, including a TNF-alpha, a luteinizing hormone, an immunoglobin, a TNF-alpha receptor, a CTLA-4, a urate oxidase, a VEGF, a PDGF, a VEGF receptor, a PDGF receptor, an interleukin-17, and/or fragments thereof, the monomers being covalently linked to one another via a linking moiety. The multimeric protein structures exhibit improved performance as compared to the corresponding native proteins, including a longer lasting activity in vivo.

    ALPHA-GALACTOSIDASE COMPOSITIONS
    4.
    发明公开
    ALPHA-GALACTOSIDASE COMPOSITIONS 审中-公开
    α-半乳糖苷酶组合物

    公开(公告)号：EP3272861A1

    公开(公告)日：2018-01-24

    申请号：EP17164713.4

    申请日：2011-09-07

    申请人： Protalix Ltd.

    发明人： SHULMAN, Avidor ,  HANANIA, Uri ,  KIZHNER, Tali ,  SHAALTIEL, Yoseph

    IPC分类号： C12N9/40 ,  A61K38/47 ,  C12N15/82 ,  A61P3/00 ,  A61P43/00

    摘要： The present invention relates to a human α-galactosidase protein having an N-terminal Glycine residue, wherein said human α-galactosidase protein is translationally fused at the C-terminal to an endoplasmic reticulum retention signal peptide.

    摘要翻译： 本发明涉及具有N-末端甘氨酸残基的人α-半乳糖苷酶蛋白，其中所述人α-半乳糖苷酶蛋白在C-末端翻译融合至内质网滞留信号肽。

    SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF
    10.
    发明公开
    SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF 有权
    SACCHARID-HALTIGE蛋白质结核病在IHRE VERWENDUNGEN

    公开(公告)号：EP2192924A2

    公开(公告)日：2010-06-09

    申请号：EP08789815.1

    申请日：2008-08-20

    申请人： Protalix Ltd.

    发明人： SHULMAN, Avidor ,  RUDERFER, Ilya

    IPC分类号： A61K47/48 ,  A61P43/00

    CPC分类号： A61K47/48092 ,  A61K47/54 ,  A61K47/549

    摘要： Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

    摘要翻译： 公开了通过非疏水性接头及其制备方法共价连接的糖和生物分子的缀合物。 还公开了利用这种缀合物的医学用途。 还公开了用于制备这些缀合物的糖基化试剂。 还公开了以改进的性能为特征的糖基化蛋白质。