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1.发明公开CYCLIC UREA- OR LACTAM-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF 审中-公开环孢菌素维生素D-VERBINDUNGEN VERWENDUNGEN DAVON CYCLISCHE HARNSTOFF- ODER LACTAMSUBSTITUIERTE CHINOXALIN-PIPERIDIN-VERBINDUNGEN
公开(公告)号：EP2880033A1
公开(公告)日：2015-06-10
申请号：EP13765756.5
申请日：2013-07-29
发明人： UENO, Tatsuhiko , TSUNO, Naoki
IPC分类号： C07D471/08 , C07D498/08 , A61K31/498 , A61P3/00 , A61P25/00
CPC分类号： C07D401/14 , C07D471/08 , C07D498/08
摘要： The disclosure relates to Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein R
1 , R
2 , Q
a , Y
1 , Z, A, B, Q
x , E, G, J, M, U, W, and a are as defined herein, compositions comprising an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxal ine-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound.摘要翻译： 本公开涉及式（I）的环状脲或内酰胺取代的喹喔啉型哌啶化合物及其药学上可接受的衍生物：其中R1，R2，Qa，Y1，Z，A，B，Qx，E，G， M，U，W和a如本文所定义，包含有效量的环脲或内酰胺取代的喹喔啉型哌啶化合物的组合物，以及治疗或预防诸如疼痛的病症的方法，包括给予 有需要的动物有效量的循环尿素或内酰胺取代的喹喔啉哌啶化合物。
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2.发明授权SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF 有权的取代的CHINOXALINTYP和桥连哌啶及其用途
公开(公告)号：EP2324013B1
公开(公告)日：2012-09-19
申请号：EP09786064.7
申请日：2009-07-20
IPC分类号： C07D403/04 , A61K31/498 , A61P25/04
CPC分类号： C07D471/08 , C07D403/04 , C07D451/14
摘要： The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.
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3.发明公开SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF 有权的取代的CHINOXALINTYP和桥连哌啶及其用途
公开(公告)号：EP2324013A1
公开(公告)日：2011-05-25
申请号：EP09786064.7
申请日：2009-07-20
IPC分类号： C07D403/04 , A61K31/498 , A61P25/04
CPC分类号： C07D471/08 , C07D403/04 , C07D451/14
摘要： The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.
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4.发明公开
公开(公告)号：EP2797912A1
公开(公告)日：2014-11-05
申请号：EP12813964.9
申请日：2012-11-30
发明人： TAFESSE, Laykea , TSUNO, Naoki , ZHOU, Xiaoming
IPC分类号： C07D401/14 , A61K31/498 , A61P25/04
CPC分类号： C07D413/14 , C07D401/14
摘要： The disclosure relates to Azetidine-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein the R
1 , R
2 , R
3 , Q, Y
1 , Z, A, B, a, and b are as defined herein, compositions comprising an effective amount of an Azetidine-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Azetidine-Substituted Quinoxaline-Type Piperidine Compound.-
5.发明公开
公开(公告)号：EP2086958A2
公开(公告)日：2009-08-12
申请号：EP08806986.9
申请日：2008-08-29
发明人： GOEHRING, Richard, R. , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, William, Frank , YAO, Jiangchao
IPC分类号： C07D401/04 , C07D401/14 , C07D451/04 , C07D451/14 , C07D471/14 , A61K31/498 , A61K31/4985 , A61P25/04
CPC分类号： C07D451/14 , A61K31/498 , C07D401/04 , C07D401/14 , C07D451/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D498/08 , C07D519/00
摘要： The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds of formula (I) or formula (II), compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound. Formula (I) or Formula (II).
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6.发明授权SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS AND THE USES THEREOF 有权的取代的CHINOXALINTYP和桥连哌啶及其用途
公开(公告)号：EP2324013B3
公开(公告)日：2014-10-22
申请号：EP09786064.7
申请日：2009-07-20
IPC分类号： C07D403/04 , A61K31/498 , A61P25/04
CPC分类号： C07D471/08 , C07D403/04 , C07D451/14
摘要： The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Bridged-Piperidine Compound.
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7.发明授权
公开(公告)号：EP2086958B1
公开(公告)日：2015-01-14
申请号：EP08806986.9
申请日：2008-08-29
发明人： GOEHRING, Richard, R. , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, William, Frank , YAO, Jiangchao , FUCHINO, Kouki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/04 , C07D451/14 , C07D471/14 , A61K31/498 , A61K31/4985 , A61P25/04
CPC分类号： C07D451/14 , A61K31/498 , C07D401/04 , C07D401/14 , C07D451/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D498/08 , C07D519/00
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公开(公告)号：EP3917621A1
公开(公告)日：2021-12-08
申请号：EP20704594.9
申请日：2020-01-30
申请人： Purdue Pharma LP
发明人： ORTIZ, Ronnie , IGO, David , TSUNO, Naoki , FUKUDA, Mayu , MIYAKE, Naoki
IPC分类号： A61P25/20 , C07D451/04 , A61K31/498
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9.发明公开NIROGENOUS HETEROCYCLIC DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS 审中-公开NITROGENE HETEROCYCLISCHE DERIVATE，DIE MIT CYCLISCHEN GRUPPEN SUBSTITUIERT SIND
公开(公告)号：EP1988077A1
公开(公告)日：2008-11-05
申请号：EP07714666.0
申请日：2007-02-21
申请人： SHIONOGI & CO., LTD.
IPC分类号： C07D209/08 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/538 , A61P25/02 , A61P25/04 , A61P25/14 , A61P25/18 , A61P39/00 , A61P43/00 , C07D209/34 , C07D263/58 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D209/08 , C07D209/34 , C07D215/38 , C07D235/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D277/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D513/04
摘要： It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.
A compound represented by:
wherein Z is N or CR 1 , A 1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A 2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R 1 , R 2 , R a , R b , R c and R d are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is -(CR 3 R 4 )m-, -CO(CR 3 R 4 )n-, -CONR 5 (CR 3 R 4 )n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R 3 and R 4 are each independently hydrogen, halogen, hydroxy etc., and R 5 is hydrogen or lower alkyl,
or a pharmaceutically acceptable salt, or a solvate thereof.摘要翻译： 发现式（I）所示的含氮杂环衍生物与NR1 / NR2B的受体特异性结合，用作NR2B受体拮抗剂。 由下式表示的化合物：其中Z为N或CR 1，A 1为任选取代的含氮芳香族单环基，任选取代的含氮芳香族稠合环基等，A 2为芳香族烃环 基团或芳族杂环基团，各自任选具有取代基，R 1，R 2，R a，R b，R c和R d各自独立地为氢，羟基等，w为2或3，t为1或 2，X为 - （CR 3 R 4）m - ， - CO（CR 3 R 4）n - ， - CONR 5（CR 3 R 4）n-等，m为1〜4的整数，n为 0〜4的整数，R 3和R 4各自独立地为氢，卤素，羟基等，R 5为氢或低级烷基，或其药学上可接受的盐或溶剂合物。
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公开(公告)号：EP3101018B1
公开(公告)日：2019-03-06
申请号：EP16176601.9
申请日：2008-08-29
发明人： GOEHRING, R. Richard , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, W., F. , YAO, Jiangchao , FUCHINO, Kouki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/04 , C07D451/14 , C07D471/14 , A61K31/498 , A61K31/4985 , A61P25/04
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