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公开(公告)号：EP3930709A1
公开(公告)日：2022-01-05
申请号：EP20762421.4
申请日：2020-02-28
发明人： BOLEN, Joseph , BONNER, Daniel Kenneth , KARANAM, Ketki , PORTER, Christopher John , SIMPSON, Jamie , TREVASKIS, Natalie , ZHENG, Dan , LEONG, Nathania , SHARMA, Garima , MCINERNEY, Mitchell , QUACH, Tim , HAN, Sifei
IPC分类号： A61K31/407 , C07D487/02 , C07D487/04
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公开(公告)号：EP4434541A2
公开(公告)日：2024-09-25
申请号：EP24188851.0
申请日：2020-01-23
发明人： KOIDE, Shohei , MILLER, George , KOIDE, Akiko , PANCHENKO, Tatyana , HATTORI, Takamitsu , FILIPOVIC, Aleksandra , ELENKO, Eric , BOLEN, Joseph
IPC分类号： A61K39/00
CPC分类号： C07K16/2809 , C07K2317/5520130101 , C07K2317/3320130101 , C07K2317/9220130101 , C07K2317/5220130101 , C07K2317/9420130101 , C07K2317/73220130101 , C07K2317/7320130101 , C07K2317/7620130101 , A61K2039/50720130101 , A61K2039/50520130101
摘要： Disclosed herein are antibodies specific to a delta-1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti-Delta1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.
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公开(公告)号：EP4087406A1
公开(公告)日：2022-11-16
申请号：EP21738535.0
申请日：2021-01-08
申请人： PureTech LYT, Inc.
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公开(公告)号：EP4035659A1
公开(公告)日：2022-08-03
申请号：EP22151613.1
申请日：2017-11-29
申请人： PureTech LYT, Inc.
发明人： BOLEN, Joseph , BONNER, Daniel Kenneth , FERREIRA, Lisa V. , KRUMOVA, Katerina , JANTZ, John , MUTAMBA, James Tendai , SHYAM, Rishab R.
摘要： The present invention provides exosomes as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within such exosomes, methods of producing such exosomes and compositions thereof, as well as methods of delivering such exosomes and compositions to a specific patient tissue or organ. The present invention also provides methods of treating a disease, disorder, or condition such as cancer, an inflammatory disease, an infectious disease, an allergic disease, or an autoimmune disease, comprising administering to a patient in need thereof a provided therapeutic-loaded exosome or a pharmaceutical composition thereof.
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公开(公告)号：EP4007640A1
公开(公告)日：2022-06-08
申请号：EP20846431.3
申请日：2020-08-03
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公开(公告)号：EP3947462A1
公开(公告)日：2022-02-09
申请号：EP20777910.9
申请日：2020-03-25
发明人： KOIDE, Shohei , MILLER, George , KOIDE, Akiko , CHEN, Linxiao , FILIPOVIC, Aleksandra , ELENKO, Eric , BOLEN, Joseph
IPC分类号： C07K16/28 , A61K39/395 , C07K14/47 , G01N33/563 , G01N33/574 , A61P35/00
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公开(公告)号：EP3962954A1
公开(公告)日：2022-03-09
申请号：EP20798582.1
申请日：2020-05-01
发明人： KOIDE, Shohei , MILLER, George , KOIDE, Akiko , CHEN, Linxiao , FILIPOVIC, Aleksandra , ELENKO, Eric , BOLEN, Joseph
IPC分类号： C07K16/28 , A61P37/06 , A61K39/395 , G01N33/574 , A61P35/00
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公开(公告)号：EP3914269A2
公开(公告)日：2021-12-01
申请号：EP20745693.0
申请日：2020-01-23
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公开(公告)号：EP3817564A1
公开(公告)日：2021-05-12
申请号：EP19830068.3
申请日：2019-07-02
申请人： PureTech LYT, Inc.
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公开(公告)号：EP4232089A1
公开(公告)日：2023-08-30
申请号：EP21887354.5
申请日：2021-10-26
申请人： PureTech LYT, Inc.
IPC分类号： A61K39/395 , A61P35/00 , C12N15/13 , G01N33/50 , G01N33/574 , G01N33/68
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