公开(公告)号：EP1556427A2

公开(公告)日：2005-07-27

申请号：EP03750435.4

申请日：2003-08-25

申请人： Röhm GmbH & Co. KG

发明人： MENZLER, Stefan ,  PETEREIT, Hans-Ulrich ,  MEIER, Christian ,  BOLLER, Thomas ,  SÜFKE, Thomas ,  SCHULTES, Klaus ,  RECKTENWALD, Roger

IPC分类号： C08F246/00 ,  C08F220/28 ,  C12N11/08

CPC分类号： C08F220/28 ,  C08F246/00 ,  Y10S530/815

摘要： The invention concerns a macroporous material in the form of plastic pearls, having an average particle diameter ranging between 10 and 1000 νm, containing a copolymer consisting of: a) 5 to 60 wt. % of monomers capable of being subjected to vinyl polymerization, being at least 1 % water soluble at 20 °C; b) 1 to 40 wt. % of monomers capable of being subjected to vinyl polymerization, comprising an additional functional group capable of being covalently bound to nucleophilic groups of ligands, during a polymerization-like reaction; c) 10 to 40 wt. % of hydrophilic monomers capable of being subjected to a crosslinking free radical polymerization, comprising at least two ethylenically unsaturated polymerisable groups; and d) 10 to 60 wt. % of monomers capable of the subjected to vinyl polymerization, not more than 1 % water soluble at 20 °C, the sum of the monomers a) through d) being generally equal to 100 %.

公开(公告)号：EP1466006A1

公开(公告)日：2004-10-13

申请号：EP03775191.4

申请日：2003-10-16

申请人： Röhm GmbH & Co. KG

发明人： MENZLER, Stefan ,  BOLLER, Thomas ,  PETEREIT, Hans-Ulrich ,  MEIER, Christian

IPC分类号： C12P35/04

CPC分类号： C12P35/04

摘要： The invention relates to a method for producing cephalexin with the aid of a penicillin amidase that is immobilized on a pearl-shaped, cross-linked and hydrophilic copolymer that binds to ligands having nucleophilic groups.