公开(公告)号：EP1737450A1

公开(公告)日：2007-01-03

申请号：EP05721534.5

申请日：2005-03-18

申请人： R-Tech Ueno, Ltd. ,  Astellas Pharma Inc.

发明人： UENO, Ryuji ,  HIRATA, Ryu ,  HARADA, Yasuhiro

IPC分类号： A61K31/426 ,  C07D277/38 ,  C07D417/06

CPC分类号： C07D417/12 ,  A61K31/426 ,  C07D277/46 ,  C07D277/56 ,  C07D417/06

摘要： The present invention provides an aqueous composition comprising a thiazole derivative of the formula (I): R1-NH-X-Y-Z (I) wherein each symbol is as defined above, or a parmaceutically acceptable salt thereof, and an additive selected from the group consisting of polyol, sugar, sugar alcohol, boric acid or its salt, and water. The aqueous composition is very stable and can be stored for a long time.

公开(公告)号：EP1737450B1

公开(公告)日：2009-09-16

申请号：EP05721534.5

申请日：2005-03-18

申请人： R-Tech Ueno, Ltd. ,  Astellas Pharma Inc.

发明人： UENO, Ryuji ,  HIRATA, Ryu ,  HARADA, Yasuhiro

IPC分类号： A61K31/426 ,  C07D277/38 ,  C07D417/06

CPC分类号： C07D417/12 ,  A61K31/426 ,  C07D277/46 ,  C07D277/56 ,  C07D417/06

摘要： The present invention provides an aqueous composition comprising a thiazole derivative of the formula (I): R1-NH-X-Y-Z (I) wherein each symbol is as defined above, or a parmaceutically acceptable salt thereof, and an additive selected from the group consisting of polyol, sugar, sugar alcohol, boric acid or its salt, and water. The aqueous composition is very stable and can be stored for a long time.

公开(公告)号：EP1984027B1

公开(公告)日：2015-12-30

申请号：EP07707565.3

申请日：2007-01-23

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HIRATA, Ryu ,  HARADA, Yasuhiro ,  UENO, Ryuji

IPC分类号： A61K47/14 ,  A61K47/10 ,  A61K9/48 ,  A61K31/352 ,  A61K47/12 ,  A61K47/26 ,  A61K9/08 ,  A61K47/36 ,  A61K31/353 ,  A61K31/382 ,  A61K31/4741

CPC分类号： A61K9/4858 ,  A61K9/08 ,  A61K31/352 ,  A61K31/353 ,  A61K31/382 ,  A61K31/4741 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36

公开(公告)号：EP2178516B1

公开(公告)日：2015-09-09

申请号：EP08778342.9

申请日：2008-07-16

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HARADA, Yasuhiro ,  KAWASAKI, Junichi ,  NISHIMURA, Yoshie ,  UENO, Ryuji

IPC分类号： A61K9/48 ,  A61K31/5575

CPC分类号： A61K47/14 ,  A61K9/4858 ,  A61K31/5575

摘要： Provided is a pharmaceutical composition comprising a 11-deoxy-prostaglandin compound represented by formula (I): and a fatty acid ester. By mixing the compound of formula (I) and a fatty acid ester, the compound of formula (I) will be stabilized.

公开(公告)号：EP2178516A2

公开(公告)日：2010-04-28

申请号：EP08778342.9

申请日：2008-07-16

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HARADA, Yasuhiro ,  KAWASAKI, Junichi ,  NISHIMURA, Yoshie ,  UENO, Ryuji

IPC分类号： A61K9/48 ,  A61K31/5575

CPC分类号： A61K47/14 ,  A61K9/4858 ,  A61K31/5575

摘要： Provided is a pharmaceutical composition comprising a 11-deoxy-prostaglandin compound represented by formula (I): and a fatty acid ester. By mixing the compound of formula (I) and a fatty acid ester, the compound of formula (I) will be stabilized.

公开(公告)号：EP1978944A2

公开(公告)日：2008-10-15

申请号：EP07707560.4

申请日：2007-01-23

申请人： R-Tech Ueno, Ltd.

发明人： HASHITERA, Yukiko ,  HIRATA, Ryu ,  HARADA, Yasuhiro ,  UENO, Ryuji

IPC分类号： A61K9/48 ,  A61K31/5575

CPC分类号： A61K31/352 ,  A61K9/4816 ,  A61K9/4825 ,  A61K9/4858 ,  A61K31/557 ,  A61K31/5575

摘要： The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.

公开(公告)号：EP1994933B1

公开(公告)日：2017-04-26

申请号：EP07738306.5

申请日：2007-03-12

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HIRATA, Ryu ,  HARADA, Yasuhiro ,  UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61K9/08 ,  A61K47/18 ,  A61K47/44 ,  A61P27/02 ,  A61K9/00

CPC分类号： A61K9/0048 ,  A61K9/08 ,  A61K9/48 ,  A61K31/5575 ,  A61K47/44

公开(公告)号：EP2700429A1

公开(公告)日：2014-02-26

申请号：EP12774428.2

申请日：2012-04-13

申请人： R-Tech Ueno, Ltd.

发明人： UNO, Tomoko ,  HAYASHI, Tadashi ,  HARADA, Yasuhiro ,  TAJIMA, Masahiro

IPC分类号： A61M35/00 ,  A45D34/04

CPC分类号： A61M35/003 ,  A45D34/04

摘要： The present invention provides an applicator, which holds an intended quantity of liquid medicament and applies the same to skin or mucous membrane without wasting. The applicator comprises a grip portion 10 for grasping; a neck portion 12, which can be elastically deflected, continuous from the grip portion 10; and a head portion 13, having a slit 14 for holding the liquid medicament supplied, continuous from the neck portion 12. When the head portion 13 is pressed against the skin or the mucous membrane, the liquid medicament is applied there while the neck portion 12 is elastically deflected.

摘要翻译： 本发明提供了一种施用器，其保持预定量的液体药物并将其施用于皮肤或粘膜而不浪费。 涂抹器包括用于抓握的握持部分10; 颈部12可从手柄部分10弹性偏转连续; 以及头部13，其具有狭缝14，用于保持从颈部12连续供应的液体药物。当头部13被压靠在皮肤或粘膜上时，液体药物被施加到颈部12 弹性偏转。

公开(公告)号：EP2696876A1

公开(公告)日：2014-02-19

申请号：EP12771895.5

申请日：2012-04-11

申请人： R-Tech Ueno, Ltd.

发明人： MASHIMA, Yukihiko ,  HARADA, Yasuhiro ,  KAWASAKI, Junichi ,  UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61K9/08 ,  A61K47/04 ,  A61K47/18 ,  A61K47/34 ,  A61P27/02

CPC分类号： A61K33/22 ,  A61K9/0048 ,  A61K31/5575 ,  A61K47/14

摘要： Disclosed is an aqueous ophthalmic composition comprising (a) a fatty acid derivative such as a prostaglandin derivative, (b) a polyoxyethylene sorbitan fatty acid ester, (c) an edetic acid compound, (d) a boric acid and a salt of a boric acid, (e) a pharmaceutically acceptable aqueous carrier, and (f) no more than 0.005w/v% of benzalkonium chloride. The composition is stable and has good anti-microbial properties.

公开(公告)号：EP1994933A1

公开(公告)日：2008-11-26

申请号：EP07738306.5

申请日：2007-03-12

申请人： R-Tech Ueno, Ltd.

发明人： HIRATA, Ryu ,  HARADA, Yasuhiro ,  UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61K9/08 ,  A61K47/18 ,  A61K47/44 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K9/08 ,  A61K9/48 ,  A61K31/5575 ,  A61K47/44

摘要： In an aqueous composition comprising a 15-keto-prostaglandin compound as an active ingredient, a polyoxyethylene castor oil derivative is admixed. By admixing a polyoxyethylene castor oil derivative, the solubility of the 15-keto-PG compound in water is increased. In a preferable embodiment, the aqueous composition may further comprise a quaternary ammonium type cationic surface active agent as a preservative. The composition of this embodiment exhibits high antimicrobial preservative effectiveness against indigenous bacterium in the eyes such as Staphylococcus aureus and therefore, the composition is especially useful as ophthalmic composition for ocular topical administration.

摘要翻译： 在含有作为活性成分的15-酮 - 前列腺素化合物的水性组合物中，混合聚氧乙烯蓖麻油衍生物。 通过混合聚氧乙烯蓖麻油衍生物，增加了15-酮-PG化合物在水中的溶解度。 在优选的实施方案中，水性组合物还可以包含作为防腐剂的季铵型阳离子表面活性剂。 该实施方案的组合物对眼睛中的本土细菌如金黄色葡萄球菌表现出高抗微生物防腐效果，因此该组合物特别可用作眼部局部给药的眼用组合物。