摘要:
A method for treating human tumours by gene therapy is disclosed. In particular, defective recombinant viruses with a sequence coding for a human tumour-specific antigen, and the use thereof for treating or preventing human tumours, as well as producing specific cytotoxic T-cells (CTLs) in vitro or ex vivo, are disclosed. Pharmaceutical compositions comprising said viruses, particularly in injectable form, are also disclosed.
摘要:
Use of a recombinant adenovirus of animal origin containing a heterologuous DNA sequence for the preparation of a pharmaceutical composition for use in the therapeutic and/or surgical treatment of the human body.
摘要:
Recombinant adenoviruses comprising a heterologous DNA sequence, preparation thereof, and use thereof for the treatment and/or prevention of cancer.
摘要:
A medicinal combination of at least one immunosuppressive agent and at least one recombinant adenovirus with a genome that includes a first recombinant DNA containing a therapeutic gene, and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in in vivo and/or ex vivo exogenic transfections.