公开(公告)号：EP3320100A1

公开(公告)日：2018-05-16

申请号：EP16823589.3

申请日：2016-07-11

申请人： University of Guelph

发明人： PEI, Yanlong ,  ACKFORD, James ,  CORREDOR, Juan Carlos ,  KRELL, Peter J. ,  NAGY, Éva

IPC分类号： C12N15/861 ,  A61K39/00 ,  C12N15/34 ,  C12N5/10 ,  C12N7/01

CPC分类号： C12N15/86 ,  C12N2510/00 ,  C12N2710/10243 ,  C12N2830/00 ,  C12N2830/48

摘要： Described are recombinant viral vectors obtained from fowl adenovirus 9 (FAdV-9) and associated methods. The recombinant FAdV-9 vectors may include one or more deletions at the left end and/or right end of the FAdV-9 genome. Optionally, the vectors include one or more exogenous nucleotide sequences, such a sequences encoding for a polypeptide of interest. The recombinant FAdV-9 vectors may be used as a dual delivery vector. Also described is the use of the vectors for generating an immunogenic response in a subject and/or for the prevention of disease.

公开(公告)号：EP0690912B1

公开(公告)日：2008-03-05

申请号：EP94912411.9

申请日：1994-04-14

申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

发明人： SHEPPARD, Michael ,  ERNY, Katrina ,  McCOY, Richard ,  WERNER, Wendy

IPC分类号： C12N15/86 ,  C12N7/01 ,  C12N15/33 ,  A61K39/235 ,  C07K14/08

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10234 ,  C12N2710/10243 ,  C12N2720/10022 ,  C12N2720/10034

公开(公告)号：EP1652931A2

公开(公告)日：2006-05-03

申请号：EP06001083.2

申请日：1994-04-15

申请人： Aventis Pharma S.A.

发明人： Perricaudet, Michel ,  Haddada, Hedi ,  May, Evelyne

IPC分类号： C12N15/86 ,  A61K48/00 ,  C12N15/12 ,  C12N15/11 ,  C12N15/861

CPC分类号： C07K14/82 ,  A61K35/761 ,  A61K38/1758 ,  A61K48/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10243 ,  C12N2710/10332 ,  C12N2710/10343 ,  A61K2300/00

摘要： La présente invention concerne des adénovirus recombinants comportant une séquence d'ADN hétérologue, leur préparation, et leur utilisation pour le traitement et/ou la prévention des cancers.

摘要翻译： 缺陷型重组腺病毒包含一个异源DNA序列（I）中，靶细胞中的表达在这有助于细胞分裂的抑制。

公开(公告)号：EP0400047B1

公开(公告)日：1997-04-23

申请号：EP89902467.3

申请日：1989-02-02

申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ,  HOWARD HUGHES MEDICAL INSTITUTE

发明人： WILSON, James M., Howard Hughes Medical Institute ,  MULLIGAN, Richard, C.

IPC分类号： C12N5/00 ,  C12N15/00

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C07K14/635 ,  C07K14/705 ,  C12N2710/10243 ,  C12N2740/13043 ,  Y10S435/948

摘要： Genetically engineered or transduced hepatocytes which express genetic material of interest introduced or incorporated into them, as well as methods of producing, transplanting and using the genetically engineered hepatocytes. The genetic material of interest can be incorporated through use of a vector, such as a recombinant retrovirus, which contains the genetic material of interest, or by other means.

公开(公告)号：EP0648271A1

公开(公告)日：1995-04-19

申请号：EP92918712.0

申请日：1992-08-20

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： CRYSTAL, Ronald, G.

IPC分类号： A01K67 ,  A61K31 ,  A61K35 ,  A61K47 ,  A61K48 ,  C07K14 ,  C12N15 ,  C12P21 ,  C12R1

CPC分类号： C12N7/00 ,  A61K47/6943 ,  A61K48/00 ,  C07K14/8125 ,  C12N15/86 ,  C12N2710/10243

摘要： The present invention relates, in general, to an adenovirus mediated transfer of genes to the gastrointestinal tract. In particular, the present invention relates to a method of recombinant, replication-deficient adenovirus mediated transfer of therapeutic genes to the gastrointestinal tract whereby therapeutic proteins for systemic and/or local purposes are produced.

公开(公告)号：EP1221490B1

公开(公告)日：2005-02-02

申请号：EP00961245.8

申请日：2000-09-14

申请人： TGT Laboratories, S.A. de C.V.

发明人： ARMENDARIZ BORUNDA, Juan ,  AGUILAR CORDOVA, Estuardo

IPC分类号： C12N15/861 ,  C12N9/64 ,  A61K38/48 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K48/00 ,  C12N9/6491 ,  C12N15/86 ,  C12N2710/10243 ,  C12N2830/008

摘要： The invention describes recombinant adenoviral vectors, in which reading frames E1 and/or E3 have been selected, said frames containing a therapeutic gene selected from amongst the gene of metaloprotease, a gene that activates the plasminogen derived from the urokinase (uPA) and the hepatocyte growth factor gene (HGF) among others. The invention also describes methods for preparing said vectors, compositions prepared with said vectors and the use thereof in genic therapy of different types of fibrosis.

公开(公告)号：EP1232248A1

公开(公告)日：2002-08-21

申请号：EP00965097.9

申请日：2000-09-15

申请人： Chemogen, Inc. ,  Blyden, Eluemuno R. ,  Grabko, Vladimir I.

发明人： GRABKO, Vladimir, I. ,  BLYDEN, Eluemuno, R.

IPC分类号： C12N7/00 ,  C12N5/00 ,  C12N5/02 ,  C07H21/02

CPC分类号： C12N15/86 ,  C12N2710/10243

摘要： We describe a new technology for producing eggs containing recombinant proteins based on the novel use of avian adenoviruses (AAV). Adenovirus infected embryonated eggs are used as the host organism. The proteins synthesized are isolated in high amounts per egg and purified excluding time-consuming steps of purification. As far as is known, the mechanisms of translation and post-translational modification of proteins in avian species fully resembles those of other higher eukaryotes such as humans, veterinary animals, and plants. In contrast with bacterial, yeast and plant host systems for producing recombinant proteins, avian embryos allow isolation of proteins in biologically active form free of endotoxins. The combination of high productivity and possibility of obtaining proteins in native form makes the system a unique choice for biotechnology, much more favorable than other hosts currently being used for this purpose.

公开(公告)号：EP1115878A1

公开(公告)日：2001-07-18

申请号：EP99947348.1

申请日：1999-09-14

申请人： Boehringer Ingelheim International GmbH

发明人： COTTEN, Matthew ,  MICHOU, Anne-Isabelle ,  CHRISTOFORI, Gerhard ,  COMPAGNI, Amelia

IPC分类号： C12N15/86 ,  A61K35/76

CPC分类号： C12N15/86 ,  A61K38/00 ,  C07K14/005 ,  C12N2710/10222 ,  C12N2710/10243

摘要： Recombinant CELO virus or CELO virus DNA with a deletion at the right end of the viral genome that allows insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in particular birds, and for gene therapy and vaccine applications in humans. The virus can also be used for recombinant protein production.

公开(公告)号：EP0904394A1

公开(公告)日：1999-03-31

申请号：EP97919383.0

申请日：1997-04-18

申请人： Boehringer Ingelheim International GmbH

发明人： BAKER, Adam ,  COTTEN, Matthew ,  CHIOCCA, Susanna ,  KURZBAUER, Robert ,  SCHAFFNER, Gotthold

IPC分类号： C12N15 ,  A61K31 ,  A61K39 ,  A61K48 ,  A61P31 ,  A61P35 ,  C07K14 ,  C12N5 ,  C12N7 ,  C12R1

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/525 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10222 ,  C12N2710/10243

摘要： The invention relates to a chicken embryo lethal orphan (CELO) virus obtained by in vitro manipulation of plasmid-cloned CELO virus DNA. Said virus is suitable for production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, in particular birds.

公开(公告)号：EP0690912A1

公开(公告)日：1996-01-10

申请号：EP94912411.0

申请日：1994-04-14

申请人： ARTHUR WEBSTER PTY. LTD.

发明人： SHEPPARD, Michael ,  ERNY, Katrina ,  McCOY, Richard ,  WERNER, Wendy

IPC分类号： C12N15 ,  A61K9 ,  A61K39 ,  A61P31 ,  C07K14 ,  C12N7

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10234 ,  C12N2710/10243 ,  C12N2720/10022 ,  C12N2720/10034

摘要： This invention relates to a recombinant vector comprising a recombinant avian adenovirus incorporating, and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of infectious bursal disease virus. The invention further relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting poultry from disease.