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1.发明公开NUCLEIC ACID MOLECULES WITH NOVEL CHEMICAL COMPOSITIONS CAPABLE OF MODULATING GENE EXPRESSION 审中-公开与新的化学成分NUKEINSÄURE分子有能力的基因的表达来调节
公开(公告)号：EP1071753A2
公开(公告)日：2001-01-31
申请号：EP99919896.3
申请日：1999-04-19
发明人： THOMPSON, James, D. , BEIGELMAN, Leonid , MCSWIGGEN, James, A. , KARPEISKY, Alexander , BELLON, Laurent , REYNOLDS, Mark , ZWICK, Michael , JARVIS, Thale , WOOLF, Tod , HAEBERLI, Peter , MATULIC-ADAMIC, Jasenka
IPC分类号： C12N9/00
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
摘要： The invention features nucleic acid molecules with novel combinations of chemical modifications which are able to modulate gene expression.
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2.发明公开METHOD AND REAGENTS FOR THE TREATMENT OF DISEASES OR CONDITIONS RELATED TO MOLECULES INVOLVED IN ANGIOGENIC RESPONSES 审中-公开疾病和疾病的治疗与血管新生相关的方法和物质相关的因素
公开(公告)号：EP1086212A2
公开(公告)日：2001-03-28
申请号：EP99915032.9
申请日：1999-03-24
发明人： PAVCO, Pamela, A. , ROBERTS, Elisabeth , JARVIS, Thale , COESHOTT, Claire , MCSWIGGEN, James, A.
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/321 , C12N2310/33
摘要： Nucleic acid molecule which modulate the synthesis, expression and/or stability of an mRNA encoding for angiogenic factors selected from aryl hydrocarbon nuclear transport (ARNT), intergrin subunit beta 3 (β3), integrin subunit alpha 6 (α6) and tie - 2 RNA. This invention further provides a treatment for indications related to angiogenesis using the nucleic acid molecules.
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公开(公告)号：EP0980424A2
公开(公告)日：2000-02-23
申请号：EP98920299.9
申请日：1998-05-05
发明人： JARVIS, Thale , MATULIC-ADAMIC, Jasenka , REYNOLDS, Mark , KISICH, Kevin , BELLON, Laurent , PARRY, Tom , BEIGELMAN, Leonid , MCSWIGGEN, James, A. , KARPEISKY, Alexander , BURGIN, Alex , THOMPSON, James , WORKMAN, Christopher, T. , BEAUDRY, Amber , SWEEDLER, David
IPC分类号： C12N9/00
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12Y204/02001 , C12Y207/01037 , C12N2310/3521
摘要： Nucleic acid catalysts which modulate the expression of Raf gene; method of delivery, screening, identification, synthesis, deprotection, purification, of nucleic acid catalysts and processes for identification of nucleic acid molecules is described.
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公开(公告)号：EP1115859A2
公开(公告)日：2001-07-18
申请号：EP99969438.3
申请日：1999-09-20
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/346 , C12N2310/53 , C12N2310/3521
摘要： The invention features novel hairpin hybridizer nucleic acid molecules which are able to modulate gene expression; useful in target validation, gene function identification and in human therapeutics.
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5.发明公开METHOD AND REAGENT FOR TREATMENT OF ARTHRITIC CONDITIONS, INDUCTION OF GRAFT TOLERANCE AND REVERSAL OF IMMUNE RESPONSES 失效方法和试剂治疗关节炎出场，诱导移植耐受和免疫应答逆转
公开(公告)号：EP0799313A2
公开(公告)日：1997-10-08
申请号：EP95942944.0
申请日：1995-11-22
发明人： BEIGELMAN, Leonid , STINCHCOMB, Daniel T. , JARVIS, Thale , DRAPER, Kenneth , PAVCO, Pamela , MCSWIGGEN, James , GUSTOFSON, John , USMAN, Nassim , WINCOTT, Francine , MATULIC-ADAMIC, Jasenka , KARPEISKY, Alexander , THOMPSON, James D. , MODAK, Anil , BURGIN, Alex
摘要： An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.
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6.发明公开METHODS AND COMPOSITIONS FOR TREATMENT OF RESTENOSIS AND CANCER USING RIBOZYMES 失效方法和组合物治疗癌症的和再狭窄使用核酶
公开(公告)号：EP0763106A1
公开(公告)日：1997-03-19
申请号：EP95921311.0
申请日：1995-05-18
IPC分类号： C12N15 , A61K31 , A61K35 , A61K38 , A61K48 , A61P9 , A61P35 , C07H21 , C07K14 , C12N5 , C12N9 , C12R1
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N9/6491 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517 , C12N2310/3521
摘要： An enzymatic nucleic acid molecule which cleaves c-myb RNA, wherein the binding arms of said nucleic acid contain sequences complementary to the sequences defined in Tables II, XII-XXIV.
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