公开(公告)号：EP1313752B1

公开(公告)日：2011-04-20

申请号：EP01966449.9

申请日：2001-08-31

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： BEIGELMAN, Leonid ,  KARPEISKY, Alexander ,  SEREBRYANY, Vladimir ,  HAEBERLI, Peter ,  SWEEDLER, David

IPC分类号： C07H19/06 ,  C07H19/16 ,  A61K31/7052 ,  C12Q1/68

CPC分类号： C07H11/04 ,  C07H15/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

摘要： The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

公开(公告)号：EP0746614A1

公开(公告)日：1996-12-11

申请号：EP95909920.0

申请日：1995-02-23

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： STINCHCOMB, Dan T. ,  CHOWRIRA, Bharat ,  DIRENZO, Anthony ,  DRAPER, Kenneth G. ,  DUDYCZ, Lech W. ,  GRIMM, Susan ,  KARPEISKY, Alexander ,  KISICH, Kevin ,  MATULIC-ADAMIC, Jasenka ,  McSWIGGEN, James A. ,  KODAK, Anil ,  PAVCO, Pamela ,  BEIGELMAN, Leonid ,  SULLIVAN, Sean M. ,  SWEEDLER, David ,  THOMPSON, James D. ,  TRACZ, Danuta ,  USMAN, Nassim ,  WINCOTT, Francine E. ,  WOOLF, Tod

IPC分类号： C12N15 ,  A61K38 ,  A61K48

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N15/101 ,  C12N15/1131 ,  C12N15/1136 ,  C12N15/1138 ,  C12N15/85 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/122 ,  C12N2310/123 ,  C12N2310/1241 ,  C12N2310/126 ,  C12N2310/127 ,  C12N2310/32 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2310/3513 ,  C12N2310/3523 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12N2310/3535 ,  C12N2760/18511 ,  C12N2830/38

摘要： Enzymatic RNA molecules which cleave ICAM-1 mRNA, IL-5 mRNA, rel A mRNA, TNF-α mRNA, RSV mRNA or RSV genomic RNA, or CML associated mRNA, and use of these molecules for the treatment of pathological conditions related to those mRNA-levels; ribonucleosides or nucleotides modified in 2', 3' or 5', methods for their synthesis, purification and deprotection; vectors containing multiple enzymatic nucleic acids, optionally in chimeric form with tRNAs; method for introducing enzymatic nucleic acids into cells by forming a complex with a second nucleic acid, where the complex is capable of taking an R-loop base-paired structure; method for altering a mutant nucleic acid in vivo by hybridization with an oligonucleotide capable of activating dsRNA deaminase, comprising an enzymatic activity or a chemical mutagen. Further are disclosed trans-cleaving or -ligating hairpin ribozymes lacking a substrate RNA moiety, as well as hammerhead ribozymes having an interconnecting loop between base pairs in stem II.

公开(公告)号：EP1313752A2

公开(公告)日：2003-05-28

申请号：EP01966449.9

申请日：2001-08-31

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： BEIGELMAN, Leonid ,  KARPEISKY, ALexander ,  SEREBRYANY, Vladimir ,  HAEBERLI, Peter ,  SWEEDLER, David

IPC分类号： C07H19/06 ,  C07H19/16 ,  A61K31/7052 ,  C12Q1/68

CPC分类号： C07H11/04 ,  C07H15/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

摘要： The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

公开(公告)号：EP1019365A1

公开(公告)日：2000-07-19

申请号：EP98935902.1

申请日：1998-07-22

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： BEIGELMAN, Leonid ,  MATULIC-ADAMIC, Jasenka ,  KARPEISKY, Alex ,  HAEBERLI, Peter ,  SWEEDLER, David ,  REYNOLDS, Mark ,  CHAUDHARY, Nilabh ,  MIN, John

IPC分类号： C07C237/06 ,  C07C237/22

CPC分类号： C07D213/64 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  C07C237/06 ,  C07C237/22 ,  C07C279/04 ,  C07C279/12 ,  C07C279/14 ,  C07H19/06 ,  C07J41/0005 ,  C07J43/003 ,  C07J51/00 ,  C12N15/88

摘要： This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.

公开(公告)号：EP1212416A2

公开(公告)日：2002-06-12

申请号：EP00963298.5

申请日：2000-08-30

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： MCSWIGGEN, James ,  USMAN, Nassim ,  BLATT, Lawrence ,  BEIGELMAN, Leonid ,  BURGIN, Alex ,  KARPEISKY, Alexander ,  MATULIC-ADAMIC, Jasenka ,  SWEEDLER, David ,  DRAPER, Kenneth ,  CHOWRIRA, Bharat ,  STINCHCOMB, Dan ,  BEAUDRY, Amber ,  ZINNEN, Shawn ,  LUGWIG, Janos ,  SPROAT, Brian, S.

IPC分类号： C12N15/11 ,  C12N9/00 ,  C07H21/00 ,  C07H19/00 ,  C12P19/34 ,  A61K31/7088 ,  C12N5/10

CPC分类号： C12N15/113 ,  A61K38/00 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C12N15/1131 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/12 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12P19/30 ,  C12P19/305 ,  C12Y207/07049 ,  C12Y301/03048 ,  C12N2310/3523

摘要： Nucleic acid molecules (antisenses or ribozymes) useful as inhibitors of gene expression, especially of HER2, BACE, TERT, PTP-1B, MetAP-2, HBV, phospholamban, presenilin-2 and PKC-alpha. The nucleic acid molecules can be modified in various ways on the sugar and/or base moieties and/or on the phosphate backbone. They are used in pharmaceutical formulations for the treatment of diseases involving increased expression of the target genes. Also disclosed is a method for the synthesis of a modified pyrimidine nucleotide triphosphate and its incorporation into an oligonucleotide.

公开(公告)号：EP1073732A2

公开(公告)日：2001-02-07

申请号：EP99921537.9

申请日：1999-04-28

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： BEIGELMAN, Leonid ,  BURGIN, Alex ,  BEAUDRY, Amber ,  KARPEISKY, Alexander ,  MATULIC-ADAMIC, Jasenka ,  SWEEDLER, David ,  ZINNEN, Shawn

IPC分类号： C12N15/11 ,  C12N9/00 ,  C07H21/00 ,  C07H19/04

CPC分类号： C12N15/113 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/345

摘要： Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed.

公开(公告)号：EP0980424A2

公开(公告)日：2000-02-23

申请号：EP98920299.9

申请日：1998-05-05

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： JARVIS, Thale ,  MATULIC-ADAMIC, Jasenka ,  REYNOLDS, Mark ,  KISICH, Kevin ,  BELLON, Laurent ,  PARRY, Tom ,  BEIGELMAN, Leonid ,  MCSWIGGEN, James, A. ,  KARPEISKY, Alexander ,  BURGIN, Alex ,  THOMPSON, James ,  WORKMAN, Christopher, T. ,  BEAUDRY, Amber ,  SWEEDLER, David

IPC分类号： C12N9/00

CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/122 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12Y204/02001 ,  C12Y207/01037 ,  C12N2310/3521

摘要： Nucleic acid catalysts which modulate the expression of Raf gene; method of delivery, screening, identification, synthesis, deprotection, purification, of nucleic acid catalysts and processes for identification of nucleic acid molecules is described.