公开(公告)号：EP2833889A4

公开(公告)日：2015-11-11

申请号：EP13773141

申请日：2013-04-04

申请人： RIGEL PHARMACEUTICALS INC

发明人： SINGH RAJINDER ,  DUNCTON MATTHEW ,  ZHANG JING ,  ALVAREZ SALVADOR ,  TSO KIN ,  HOLLAND SACHA ,  YEN ROSE ,  KOLLURI RAO ,  HECKRODT THILO ,  CHEN YAN ,  MASUDA ESTEBAN ,  LI HUI ,  PAYAN DONALD G ,  KELLEY RYAN

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/553 ,  C07D519/00 ,  C12N9/12 ,  C12Q1/485 ,  C12Y207/11013

摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：EP3286181A1

公开(公告)日：2018-02-28

申请号：EP16719191

申请日：2016-04-22

申请人： RIGEL PHARMACEUTICALS INC

发明人： KELLEY RYAN ,  LI HUI ,  HECKRODT THILO ,  CHEN YAN ,  MCMURTRIE DARREN ,  TSO KIN ,  TAYLOR VANESSA ,  SINGH RAJINDER ,  YEN ROSE ,  MAUNG JACK

IPC分类号： C07D405/14 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/426 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

CPC分类号： C07F9/65586 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.